低浓度十四烷基硫酸钠和高渗葡萄糖溶液治疗毛细血管扩张症：一项前瞻性随机临床试验。

Low concentration of sodium tetradecyl sulfate and hypertonic glucose solution for the treatment of telangiectasia: A prospective randomized clinical trial.

机构信息

The Clinic (Doctor Profi), Derzhavin Tambov State University, Tambov, Russia.

The Clinic (Mir Zdorovja), Kursk, Russia.

出版信息

Phlebology. 2023 Oct;38(9):622-627. doi: 10.1177/02683555231191969. Epub 2023 Jul 30.

DOI:10.1177/02683555231191969

PMID:37519033

Abstract

OBJECTIVES

This study aimed to compare telangiectasias disappearance after sclerotherapy with hypertonic glucose (HG) and different concentrations of sodium tetradecyl sulfate (STS).

METHODS

Women aged 18-70 years with telangiectasias were included. The primary efficacy endpoint was telangiectasia disappearance. The clearing of vessels was assessed using a six-point scale (from 0 to 5).

RESULTS

A total of 116 women completed an 8-week follow-up: 31, 27, 25, and 33 were in the HG 75%, STS 0.05%, STS 0.1%, and STS 0.15% groups, respectively. The median score of vein disappearance was significantly lower in the STS 0.05% (3, 0.25-4), STS 0.1% (3, 1.25-4), and STS 0.15% (4, 2-4) groups than in the HG group (4, 3-5) after 56 days, = .00002.

CONCLUSION

Sclerotherapy of telangiectasias with 75% HG showed significantly better results than low concentrations of STS.

TRIAL REGISTRATION

ClinicalTrials.gov NCT04132323.

摘要

目的

本研究旨在比较硬化疗法联合高渗葡萄糖（HG）与不同浓度十四烷基硫酸钠（STS）治疗毛细血管扩张症的疗效。

方法

纳入年龄在 18-70 岁之间的毛细血管扩张症女性患者。主要疗效终点为毛细血管扩张症消失。采用六点评分法（0-5 分）评估血管清除情况。

结果

共有 116 名女性完成了 8 周的随访：31、27、25 和 33 名患者分别在 HG 75%、STS 0.05%、STS 0.1%和 STS 0.15%组。在第 56 天，STS 0.05%（3，0.25-4）、STS 0.1%（3，1.25-4）和 STS 0.15%（4，2-4）组的静脉消失评分中位数明显低于 HG 组（4，3-5），差异有统计学意义（ =.00002）。