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[罗讷-阿尔卑斯大区因晕厥跌倒而入住急诊科的老年患者心血管药物使用情况研究]

[Study of cardiovascular drugs usage, among elderly subjects admitted to the emergency department for syncopal falls in Rhône-Alpes region].

作者信息

Hélias Gaëlle, Garnier Virginie, Enzinger Lukas, Eymaron Maeva, Ageron Francois-Xavier, Couturier Pascal

机构信息

Service universitaire de gériatrie et gérontologie clinique, centre gérontologique Sud, centre hospitalier universitaire, Grenoble, France.

Service des urgences, centre hospitalier universitaire Vaudois, CHUV, Lausanne, Suisse.

出版信息

Geriatr Psychol Neuropsychiatr Vieil. 2023 Jun 1;21(2):173-184. doi: 10.1684/pnv.2023.1107.

Abstract

Study of cardiovascular drugs usage, among elderly subjects admitted to the emergency department for syncopal falls in Rhône-Alpes region. Polypharmacy and cardiovascular medication usage are risk factors for falls in the elderly. This study included subjects aged 75 and over, admitted in the emergency department for falls, based on evaluation data of professional practices carried out in the Nord Alpine region by the French Network of North-Alps Emergency Departments (Réseau Nord Alpin des Urgences, RENAU). The patients included were divided into 4 groups: "syncope", "accidental falls", "repeated falls" and "other types of fall". From the emergency room admission prescriptions, we studied the consumption of cardiovascular drugs in number and quality in the "syncope" group compared to other types of falls. The main objective in this study was to highlight higher cardiovascular drug usage among the elderly patients admitted to the emergency department for syncopal falls, in comparison with other types of falls. We included 1,476 patients among whom 262 patients came for "syncopal falls". We found superior usage of cardiovascular medication among syncopal falls compared to other type of falls (p < 0,01). However, there is no statistically significant association between inappropriate cardiovascular drug prescriptions, and the type of falls. The "standardized" fall assessment whose orthostatic hypotension investigation, is not always exhaustive in the emergency room. Orthostatic hypotension diagnostic is insufficiently sought in the emergency room. This study highlights a significantly higher usage of diuretic medication within the syncope group, in comparison to the other groups, and especially loop diuretic. Antihypertensive drugs (angiotensin-converting enzyme inhibitor, angiotensin II receptor blockers, calcium inhibitor) are also recurrent within the syncope group compared to the others. A careful supervising of these prescriptions among elderly patients seems required. These data prompt to revise prescriptions during fall related hospitalizations, and then with the primary-care physician, or with the cardiologist.

摘要

罗讷-阿尔卑斯地区因晕厥跌倒而入住急诊科的老年患者心血管药物使用情况研究。多重用药和心血管药物使用是老年人跌倒的风险因素。本研究纳入了75岁及以上因跌倒入住急诊科的患者,数据基于法国北阿尔卑斯急诊科网络(Réseau Nord Alpin des Urgences,RENAU)在北阿尔卑斯地区开展的专业实践评估数据。纳入的患者分为4组:“晕厥”、“意外跌倒”、“反复跌倒”和“其他类型跌倒”。从急诊入院处方中,我们研究了“晕厥”组与其他类型跌倒相比心血管药物的数量和质量消耗情况。本研究的主要目的是突出因晕厥跌倒入住急诊科的老年患者与其他类型跌倒患者相比,心血管药物使用量更高。我们纳入了1476名患者,其中262名因“晕厥跌倒”前来就诊。我们发现晕厥跌倒患者的心血管药物使用量高于其他类型跌倒患者(p<0.01)。然而,不适当的心血管药物处方与跌倒类型之间没有统计学上的显著关联。“标准化”跌倒评估,其体位性低血压调查在急诊室并不总是详尽无遗的。急诊室对体位性低血压的诊断检查不足。本研究突出显示,与其他组相比,晕厥组利尿剂药物的使用量显著更高,尤其是袢利尿剂。与其他组相比,晕厥组中抗高血压药物(血管紧张素转换酶抑制剂、血管紧张素II受体阻滞剂、钙拮抗剂)的使用也更为频繁。似乎需要对老年患者的这些处方进行仔细监测。这些数据促使在与跌倒相关的住院期间以及随后与初级保健医生或心脏病专家一起修改处方。

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