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术前使用患者特异性有限元模拟预测胸主动脉腔内修复术中鸟嘴构型。

Prediction of bird-beak configuration in thoracic endovascular aortic repair preoperatively using patient-specific finite element simulations.

作者信息

Shahbazian Negin, Romero David A, Forbes Thomas L, Amon Cristina H

机构信息

Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada.

Division of Vascular Surgery, Department of Surgery, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, ON, Canada.

出版信息

JVS Vasc Sci. 2023 Apr 24;4:100108. doi: 10.1016/j.jvssci.2023.100108. eCollection 2023.

Abstract

OBJECTIVES

Formation of bird-beak configuration in thoracic endovascular aortic repair (TEVAR) has been shown to be correlated with the risk of complications such as type Ia endoleaks, stent graft migration, and collapse. The aim of this study was to use patient-specific computational simulations of TEVAR to predict the formation of bird-beak configuration preoperatively.

METHODS

Patient-specific TEVAR computational simulations are developed using a retrospective cohort of patients treated for thoracic aortic aneurysm. The preoperative computed tomography images were segmented to develop three-dimensional geometry of the thoracic aorta. These geometries were used in finite element simulations of stent graft deployment during TEVAR. Simulated results were compared against the postoperative computed tomography images to assess the accuracy of simulations in predicting the proximal position of a deployed stent graft and presence of bird-beak. In cases with a bird-beak configuration, the length and angle of the bird-beak were measured and compared between the simulated and postoperative results.

RESULTS

Twelve TEVAR patient cases were simulated. Computational simulations were able to accurately predict whether the proximal stent graft was fully apposed, proximal bare stents were protruded, or bird-beak configuration was present. In three cases with bird-beak configuration, simulations predicted the length and angle of the bird-beak with less than 10% and 24% error, respectively. Other factors such as a small aortic arch angle, small oversizing value, and landing zones close to the arch apex may have played a role in formation of bird-beak in these patients.

CONCLUSIONS

Computational simulations of TEVAR accurately predicted the proximal position of a deployed stent graft and the presence of bird-beak preoperatively. The computational models were able to predict the length and angle of bird-beak configurations with good accuracy. These simulations can provide insight into the surgical planning process with the goal of minimizing bird-beak occurrence.

摘要

目的

胸主动脉腔内修复术(TEVAR)中鸟嘴状结构的形成已被证明与Ia型内漏、支架移植物移位和塌陷等并发症风险相关。本研究的目的是使用TEVAR患者特异性计算模拟来术前预测鸟嘴状结构的形成。

方法

使用接受胸主动脉瘤治疗的患者回顾性队列开展TEVAR患者特异性计算模拟。对术前计算机断层扫描图像进行分割以构建胸主动脉的三维几何模型。这些几何模型用于TEVAR期间支架移植物展开的有限元模拟。将模拟结果与术后计算机断层扫描图像进行比较,以评估模拟在预测展开的支架移植物近端位置和鸟嘴状结构存在方面的准确性。在存在鸟嘴状结构的病例中,测量鸟嘴状结构的长度和角度,并比较模拟结果与术后结果。

结果

模拟了12例TEVAR患者病例。计算模拟能够准确预测近端支架移植物是否完全贴合、近端裸支架是否突出或是否存在鸟嘴状结构。在3例有鸟嘴状结构的病例中,模拟预测鸟嘴状结构的长度和角度误差分别小于10%和24%。其他因素,如小的主动脉弓角度、小的超尺寸值以及靠近弓顶的着陆区,可能在这些患者鸟嘴状结构的形成中起作用。

结论

TEVAR的计算模拟准确地术前预测了展开的支架移植物的近端位置和鸟嘴状结构的存在。计算模型能够以良好的准确性预测鸟嘴状结构的长度和角度。这些模拟可为手术规划过程提供见解,以尽量减少鸟嘴状结构的出现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ef/10372321/abd0e9b6ac6a/gr1.jpg

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