脂肪酶介导的仿生碳酸酚酯的流动合成。
Lipase-mediated flow synthesis of nature-inspired phenolic carbonates.
作者信息
Vicinanza Sara, Annunziata Francesca, Pecora Desirèe, Pinto Andrea, Tamborini Lucia
机构信息
Department of Pharmaceutical Sciences (DISFARM), University of Milan Via Mangiagalli 25 Milan 20133 Italy
Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan Via Celoria 2 Milan 20133 Italy.
出版信息
RSC Adv. 2023 Jul 28;13(33):22901-22904. doi: 10.1039/d3ra04735k. eCollection 2023 Jul 26.
A facile and convenient lipase-catalyzed flow approach for the chemoselective synthesis of tyrosol and hydroxytyrosol methyl carbonates has been developed in neat dimethylcarbonate. The products were obtained in quantitative yield with high catalyst productivity. The biocatalytic approach was then exploited for the preparation of value-added symmetrical tyrosol and hydroxytyrosol carbonates.
已开发出一种简便且便捷的脂肪酶催化流动方法，用于在纯碳酸二甲酯中化学选择性合成酪醇和羟基酪醇碳酸甲酯。产物以定量产率获得，且催化剂生产率高。然后利用这种生物催化方法制备了具有附加值的对称酪醇和羟基酪醇碳酸酯。
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