Nelson K B, Ellenberg J H
Am J Dis Child. 1986 Oct;140(10):1053-61. doi: 10.1001/archpedi.1986.02140240099034.
One or more nonfebrile seizures occurred between the ages of 1 month and 7 years in eight per 1000 white and in nine per 1000 black children enrolled in a large prospective study. We examined hundreds of prenatal and perinatal factors as predictors of childhood seizure disorders. Congenital malformations of the fetus (cerebral and noncerebral), family history of certain neurologic disorders, and neonatal seizures were the major predictors identified. Forty percent of children with postneonatal seizures and 68% of children with minor motor seizures had one or more of these risk factors compared with 21% of the seizure-free population. More than half of the children with minor motor seizures and a third of the infants with neonatal seizures had congenital malformations. Based on the prenatal and perinatal factors examined, prediction of postneonatal seizures carried a high rate of false-positive identification, indicating that our knowledge of the etiology of childhood seizure disorders is still very limited.
在一项大型前瞻性研究中，每1000名登记在册的白人儿童中有8名、黑人儿童中有9名在1个月至7岁之间发生了一次或多次无热惊厥。我们检查了数百种产前和围产期因素，作为儿童癫痫障碍的预测指标。胎儿先天性畸形（脑部和非脑部）、某些神经系统疾病的家族史以及新生儿惊厥是确定的主要预测指标。与无癫痫发作人群的21%相比，40%的新生儿期后惊厥儿童和68%的轻微运动性惊厥儿童有这些危险因素中的一种或多种。超过一半的轻微运动性惊厥儿童和三分之一的新生儿惊厥婴儿有先天性畸形。基于所检查的产前和围产期因素，新生儿期后惊厥的预测存在较高的假阳性识别率，这表明我们对儿童癫痫障碍病因的了解仍然非常有限。
