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2022年初临床肿瘤学研究亮点

Research highlights of clinical oncology early 2022.

作者信息

Wu Kaichun

机构信息

Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.

出版信息

Holist Integr Oncol. 2022;1(1):6. doi: 10.1007/s44178-022-00006-9. Epub 2022 Jul 5.

DOI:10.1007/s44178-022-00006-9
PMID:37520335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9255546/
Abstract

Advance in clinical oncology is highly relied on development of cancer research and clinical trials. There has been ample evidence regarding the new therapeutic drugs, agents or techniques for the treatment of cancer. We did a broad literature search to catch the latest progress in the cancer therapy. Here is a brief review of the newly released results of clinical trials including surgical modalities, immune checkpoint blockade, chimeric antigen receptor T-cell (CAR T) therapy, antibody-drug conjugates and tumor vaccines, etc. Biomarkers or patient assessment of cancer therapy were also discussed.

摘要

临床肿瘤学的进展高度依赖于癌症研究和临床试验的发展。关于治疗癌症的新治疗药物、制剂或技术已有充分证据。我们进行了广泛的文献检索以了解癌症治疗的最新进展。以下是对新发布的临床试验结果的简要综述,包括手术方式、免疫检查点阻断、嵌合抗原受体T细胞(CAR T)疗法、抗体药物偶联物和肿瘤疫苗等。还讨论了癌症治疗的生物标志物或患者评估。

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N Engl J Med. 2022 Mar 10;386(10):942-950. doi: 10.1056/NEJMoa2114663.
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Thyroidectomy without Radioiodine in Patients with Low-Risk Thyroid Cancer.低危甲状腺癌患者的甲状腺切除术不伴放射性碘治疗。
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Lenvatinib plus Pembrolizumab for Advanced Endometrial Cancer.仑伐替尼联合帕博利珠单抗治疗晚期子宫内膜癌。
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Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma.Relatlimab 和 Nivolumab 对比 Nivolumab 用于未经治疗的晚期黑色素瘤。
N Engl J Med. 2022 Jan 6;386(1):24-34. doi: 10.1056/NEJMoa2109970.
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