Department of Medicine, Pacific Medical College and Hospital, Pacific Medical University, Udaipur, Rajasthan, India.
Department of Pediatrics, Pacific Medical College and Hospital, Pacific Medical University, Udaipur, Rajasthan, India.
J Med Life. 2023 May;16(5):782-793. doi: 10.25122/jml-2023-0017.
Healthcare workers (HCWs) are at high risk of COVID-19 infection despite vaccination. Limited data exist on COVID-19 cases among vaccinated HCWs. This study aimed to describe the clinical characteristics and outcomes of RT PCR-confirmed COVID-19 cases in vaccinated HCWs, at a COVID clinic in a medical college hospital. This single-center, prospective cohort study included HCWs who received at least one dose of the COVID-19 vaccine and tested positive for COVID-19 within 6 months. Data on demographics, symptoms, work category, COVID-19 vaccination interval, and infection severity were collected. Of 2381 vaccinated HCWs, 105 tested positive and were categorized as mild, moderate, or severe cases. Among vaccinated HCWs, 4.41% had post-vaccine COVID-19 infections. All 105 cases received the first dose, and 79 received the second dose. Of the cases, 47.6% were partially vaccinated, and 53.3% were breakthrough cases. The mean age was 30.90±8.69 years, with 63.8% male and 36.2% female cases. Most cases (85.7%) acquired infection in the hospital, and 47.6% had direct contact with COVID-19 patients. Common symptoms included fatigue (85.7%), fever (82.9%), and cough (64.8%). Among cases, 93.3% were mild, 5.7% were moderate, and 0.9% were severe. Hospital admission and supplemental oxygen therapy were required for moderate and severe cases. No mortality was reported. Certain variables were associated with age, preventive measures, workplace type, symptoms, and comorbidities. Breakthrough infections can occur among fully vaccinated HCWs but with reduced severity and mortality. Monitoring and infection control measures remain crucial even in vaccinated individuals. This study provides insights into clinical presentations, oxygen therapy requirements, and outcomes of post-vaccine COVID-19 cases among HCWs. The data will inform strategies for booster doses to prevent COVID-19.
医护人员（HCWs）尽管已接种疫苗，但仍面临 COVID-19 感染的高风险。关于接种疫苗的 HCWs 中 COVID-19 病例的数据有限。本研究旨在描述医学院附属医院 COVID 诊所接种 COVID-19 疫苗的 HCWs 中经 RT-PCR 确诊的 COVID-19 病例的临床特征和结局。这是一项单中心前瞻性队列研究，纳入了至少接种一剂 COVID-19 疫苗且在 6 个月内 COVID-19 检测呈阳性的 HCWs。收集了人口统计学、症状、工作类别、COVID-19 疫苗接种间隔和感染严重程度的数据。在 2381 名接种疫苗的 HCWs 中，有 105 人检测呈阳性，并分为轻症、中症或重症病例。在接种疫苗的 HCWs 中，4.41%发生了疫苗接种后 COVID-19 感染。所有 105 例均接种了第一剂，79 例接种了第二剂。其中，47.6%为部分接种，53.3%为突破性病例。病例的平均年龄为 30.90±8.69 岁，男性占 63.8%，女性占 36.2%。大多数病例（85.7%）在医院感染，47.6%有与 COVID-19 患者的直接接触。常见症状包括疲劳（85.7%）、发热（82.9%）和咳嗽（64.8%）。病例中，93.3%为轻症，5.7%为中症，0.9%为重症。中症和重症病例需要住院和补充氧气治疗。无死亡报告。某些变量与年龄、预防措施、工作场所类型、症状和合并症有关。突破性感染可发生在完全接种疫苗的 HCWs 中，但严重程度和死亡率降低。即使在接种疫苗的个体中，监测和感染控制措施仍然至关重要。本研究提供了接种疫苗后 COVID-19 病例在 HCWs 中的临床表现、氧气治疗需求和结局的见解。这些数据将为预防 COVID-19 的加强针策略提供信息。
