Schairer C, Brinton L A, Hoover R N
Am J Epidemiol. 1986 Oct;124(4):603-11. doi: 10.1093/oxfordjournals.aje.a114433.
The relation between methylxanthine consumption and biopsied benign breast disease was investigated by using data from a case-control study which included 1,569 cases and 1,846 controls identified between 1973 and 1980 through a nationwide screening program. There was no evidence of an association between methylxanthine consumption and benign breast disease in the total study population. When histologic types of benign breast disease were examined, there were no trends in risk according to methylxanthine consumption among the 813 cases with fibrocystic disease, the 508 cases for whom detailed pathology data were not available, the 172 cases with benign neoplasms, or the 156 cases with other benign conditions. When cases with fibrocystic disease were examined according to presence of atypia, hyperplasia, sclerosing adenosis, or cysts, there was, again, no association between methylxanthine consumption and risk of disease. In addition, no relation was found between methylxanthine consumption and menstrual breast tenderness among premenopausal women with fibrocystic disease or unknown conditions.
通过一项病例对照研究的数据，对甲基黄嘌呤摄入量与活检确诊的良性乳腺疾病之间的关系进行了调查。该研究纳入了1973年至1980年间通过全国性筛查计划确定的1569例病例和1846例对照。在整个研究人群中，没有证据表明甲基黄嘌呤摄入量与良性乳腺疾病之间存在关联。当对良性乳腺疾病的组织学类型进行检查时，在813例纤维囊性疾病患者、508例缺乏详细病理数据的患者、172例良性肿瘤患者或156例其他良性疾病患者中，根据甲基黄嘌呤摄入量，均未发现风险趋势。当根据非典型性、增生、硬化性腺病或囊肿的存在情况对纤维囊性疾病患者进行检查时，甲基黄嘌呤摄入量与疾病风险之间同样没有关联。此外，在患有纤维囊性疾病或情况不明的绝经前女性中，未发现甲基黄嘌呤摄入量与经前乳腺压痛之间存在关系。
