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用于潜在治疗新型冠状病毒肺炎的表面功能化电纺聚乙烯醇纳米网的制备

Preparation of surface-functionalized electrospun PVA nanowebs for potential remedy for SARS-CoV-2.

作者信息

Ayodeji Olukayode J, Khyum Mirza M O, Afolabi Racheal T, Smith Ernest, Kendall Ron, Ramkumar Seshadri

机构信息

Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas, 79416, United States.

出版信息

J Hazard Mater Adv. 2022 Aug;7:100128. doi: 10.1016/j.hazadv.2022.100128. Epub 2022 Jul 13.

Abstract

Infections with coronaviruses remain a burden that is negatively affecting human life. The use of metal oxides to prevent and control the spread of severe acute respiratory syndrome coronavirus (SARS-CoV-2) has been widely studied. However, the use of metal oxides in masks to enhance the performances of barrier face coverings in trapping and neutralizing SARS-CoV-2 remained unexplored. In the present study, we explore the possibility of developing surface functional PVA/ZnO electrospun nanowebs to be used as a component of multilayer barrier face coverings. Polyvinyl alcohol (PVA) and zinc acetate (ZnA) nanowebs were electrospun as precursor samples. After calcination at 400 degrees centigrade under a controlled atmosphere of nitrogen gas, product nanowebs containing ZnO (PVA/ZnO) were obtained. The presence of ZnO was determined using an attenuated total reflectance Fourier Transform Infrared (FT-IR) spectrometer. This study inspired the possibility of developing surface-functional materials to produce enhanced performance masks against the spread of SARS-CoV-2.

摘要

冠状病毒感染仍然是一个对人类生活产生负面影响的负担。使用金属氧化物来预防和控制严重急性呼吸综合征冠状病毒(SARS-CoV-2)的传播已得到广泛研究。然而,在口罩中使用金属氧化物以提高屏障式面部覆盖物捕获和中和SARS-CoV-2的性能仍未得到探索。在本研究中,我们探索了开发表面功能化的聚乙烯醇/氧化锌(PVA/ZnO)电纺纳米纤维网作为多层屏障式面部覆盖物组件的可能性。将聚乙烯醇(PVA)和醋酸锌(ZnA)纳米纤维网作为前驱体样品进行电纺。在氮气控制气氛下于400摄氏度煅烧后,获得了含有氧化锌(PVA/ZnO)的产物纳米纤维网。使用衰减全反射傅里叶变换红外(FT-IR)光谱仪确定氧化锌的存在。这项研究激发了开发表面功能材料以生产具有增强性能的口罩来对抗SARS-CoV-2传播的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d098/9278001/814a5fc43d96/ga1_lrg.jpg

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