Mohamadianamiri Mahdiss, Aklamli Majid, Alemohammad Farzaneh
Department of Obstetrics and Gynecology, Akbarabadi Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran.
Department of Anesthesiology, Akbarabadi Hospital, Iran University of Medical Sciences, Tehran, Iran.
Caspian J Intern Med. 2023 Summer;14(3):443-448. doi: 10.22088/cjim.14.3.443.
Endometrial cancer is one the most popular types of cancer in women in the world, also a common type of cancer among Iranian females. Neutrophils to lymphocytes (NLR) and platelet to lymphocyte (PLR) ratios are two practical and available indicators in endometrial cancer. We examined their correlation in these patients and determined that they could be used as a prognostic factor in grading and staging this cancer. This study takes a practical approach and recommends a screening strategy for asymptomatic women diagnosed with cancer in its early stages.
Endometrial cancer patients were included in this cross-sectional study based on histological findings. NLR is known as the proportion of neutrophils to absolute lymphocytes, while PLR is known as the proportion of platelets to lymphocytes. The NLR and PLR were evaluated and their relationship to the grade and stage of cancer.
PLR and NLR values were calculated, and the mean values were 4.917±5.870 and 16.019±18.963, respectively. NLR and PLR were more significant in group 2 patients. Additionally, a strong and statistically significant relationship existed between these two methods (p<0.001). For the NL and PL methods, the optimal cutting point was 3.66 and 13.26, respectively. The NL method had a specificity of 0.906 and a sensitivity of 0.564. The PL and NL zones had values of 0.697 and 0.725, respectively. Although there is no remarkable difference among these areas, the AUC of PL power is slightly better than the NL method. It demonstrates that they are capable of increasing detection power by more than 50%.
This study concluded that PLR and NLR were identified as independent prognostic items associated with the stage and grade of endometrial cancer.
子宫内膜癌是全球女性中最常见的癌症类型之一，也是伊朗女性中常见的癌症类型。中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）是子宫内膜癌中两个实用且可得的指标。我们研究了它们在这些患者中的相关性，并确定它们可作为该癌症分级和分期的预后因素。本研究采用实用方法，为早期诊断为癌症的无症状女性推荐一种筛查策略。
基于组织学结果，将子宫内膜癌患者纳入本横断面研究。NLR是指中性粒细胞与绝对淋巴细胞的比例，而PLR是指血小板与淋巴细胞的比例。评估了NLR和PLR及其与癌症分级和分期的关系。
计算了PLR和NLR值，平均值分别为4.917±5.870和16.019±18.963。NLR和PLR在2组患者中更显著。此外，这两种方法之间存在强且具有统计学意义的关系（p<0.001）。对于NL和PL方法，最佳切点分别为3.66和13.26。NL方法的特异性为0.906，敏感性为0.564。PL和NL区域的值分别为0.697和0.725。尽管这些区域之间没有显著差异，但PL的AUC略优于NL方法。这表明它们能够将检测能力提高50%以上。
本研究得出结论，PLR和NLR被确定为与子宫内膜癌分期和分级相关的独立预后指标。
