斯洛伐克接受手术患者中丁酰胆碱酯酶多态性的发生情况。
Occurrence of butyrylcholinesterase polymorphisms in patients undergoing surgery in Slovakia.
作者信息
Čuchráč Lukáš, MydlárováBlaščáková Marta, Firment Jozef, Šimonová Jana, Jarmila Bernasovská, Vašková Janka
机构信息
1st Clinic of Anaesthesiology and Intensive Care Medicine, Louis Pasteur University Hospital in Košice, and PavolJozefŠafárik University in Košice, Tr. SNP 1, 040 66 Košice, Slovak Republic.
Department of Biology, Faculty of Humanities and Natural Sciences, University of Prešov in Prešov, Ul. 17 novembra 1, 081 16 Prešov, Slovak Republic.
出版信息
Caspian J Intern Med. 2023 Summer;14(3):490-494. doi: 10.22088/cjim.14.3.490.
BACKGROUND
Post-operative residual curarization is a persisting problem, characterized by muscle fatigue, exhaustion or paresis, caused by the use of neuromuscular blocking agents with prolonged postoperative effect. Genetically, determined changes in cholinesterase activity can be a major reason for persistent muscle blockade after administration of muscle relaxants.
METHODS
Regarding the subsistence of polymorphisms in the plasma cholinesterase gene causing change in enzyme activity and metabolism of applied drugs, we investigated the frequency of two polymorphisms known to reduce its activity significantly in patients undergoing surgery.
RESULTS
Primary results show a relatively high occurrence of plasma cholinesterase K risk allele (18.75%).
CONCLUSION
Characterization of the lacking information about genetic background of changes in plasma cholinesterase activity within Slovakia may allow for easier decision-making in clinical practice when selecting alternative neuromuscular blocking and also reversal agents.
背景
术后残余肌松是一个持续存在的问题，其特征为肌肉疲劳、耗竭或麻痹，这是由使用具有延长术后效应的神经肌肉阻滞剂引起的。从遗传学角度来看，胆碱酯酶活性的特定变化可能是使用肌肉松弛剂后持续性肌肉阻滞的主要原因。
方法
鉴于血浆胆碱酯酶基因多态性的存在会导致酶活性及所用药物代谢发生变化，我们调查了已知会显著降低酶活性的两种多态性在接受手术患者中的发生频率。
结果
初步结果显示血浆胆碱酯酶K风险等位基因的发生率相对较高（18.75%）。
结论
了解斯洛伐克血浆胆碱酯酶活性变化的遗传背景方面的缺失信息，可能有助于在临床实践中选择替代神经肌肉阻滞剂及逆转剂时做出更轻松的决策。
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