Dong Wen-Yi, Zhou Ming-Ju, Huang Lei, Zhang Chao, Wang Fu-Sheng, Xie Zhou-Hua
Guangxi AIDS Clinical Treatment Centre, The Fourth People's Hospital of Nanning, Nanning 530013, China.
Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Infect Dis Immun. 2022 Oct;2(4):289-292. doi: 10.1097/ID9.0000000000000041. Epub 2022 Aug 12.
Severe acute respiratory syndrome coronavirus-2 infection is usually self-limited, with a short duration for viral shedding within several weeks. However, prolonged viral shedding has been observed in severe or immune-compromised coronavirus disease 2019 (COVID-19) cases. Here, we reported that three young adult cases of COVID-19 patients, who were either immunosuppressed nor severe, showed prolonged viral RNA shedding from the upper respiratory tract for 58, 81, and 137 days since initial diagnosis. To our knowledge, this is the longest duration of viral shedding reported to date in young adult patients. Further studies on factors relevant to prolonged viral positivity, as well as the correlation between viral positivity and transmission risk are needed for the optimal management of COVID-19 patients with prolonged nucleic acid positive.
严重急性呼吸综合征冠状病毒2感染通常是自限性的，病毒在数周内的脱落持续时间较短。然而，在重症或免疫功能低下的2019冠状病毒病（COVID-19）病例中观察到了病毒脱落时间延长的情况。在此，我们报告了3例年轻成年COVID-19患者，他们既非免疫抑制也非重症，自初次诊断以来，上呼吸道病毒RNA脱落时间分别长达58天、81天和137天。据我们所知，这是迄今为止报道的年轻成年患者中病毒脱落持续时间最长的情况。对于核酸持续阳性的COVID-19患者的最佳管理，需要进一步研究与病毒阳性持续时间相关的因素，以及病毒阳性与传播风险之间的相关性。
