Hartwell Micah, Greiner Benjamin H, Nicks Savannah
Oklahoma State University Center for Health Sciences, Department of Psychiatry and Behavioral Sciences, Tulsa, Oklahoma, United States.
Oklahoma State University Center for Health Sciences, Office of Medical Student Research, Tulsa, Oklahoma, United States.
Infect Dis Immun. 2022 Oct;2(4):282-284. doi: 10.1097/ID9.0000000000000056. Epub 2022 Aug 12.
As the SARS-CoV-2 virus shares relatively large protein sequences homologous to grass pollens, dust mites, and molds, our objective was to assess the potential overlap between the COVID-19 mRNA vaccines from Pfizer-BioNtech and Moderna and known allergens. We found 7 common allergens with potential for cross-reactivity with the Pfizer vaccine and 19 with the Moderna vaccine, including common grasses, molds, and dust mites. T-cell mediated antigen cross-reactivity between viruses and allergens is a relatively new area of study in clinical immunology; a discipline that may be particularly useful regarding the SARS-CoV-2 virus and the allergic response in humans. These results suggest that vaccination with the Pfizer-BioNtech and Moderna COVID-19 vaccines may contribute to T-cell cross-reactivity with allergens that impact allergic asthma and allergic rhinitis. Further research should assess the clinical implications of COVID-19 vaccination on the severity and symptomatology of the allergic disease, in addition to natural viral infection.
由于严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒与草花粉、尘螨和霉菌具有相对较大的同源蛋白质序列，我们的目标是评估辉瑞-生物科技公司和莫德纳公司的新冠病毒mRNA疫苗与已知过敏原之间的潜在重叠情况。我们发现有7种常见过敏原可能与辉瑞疫苗发生交叉反应，19种与莫德纳疫苗发生交叉反应，包括常见的草类、霉菌和尘螨。病毒与过敏原之间由T细胞介导的抗原交叉反应是临床免疫学中一个相对较新的研究领域；这一学科对于SARS-CoV-2病毒和人类过敏反应可能特别有用。这些结果表明，接种辉瑞-生物科技公司和莫德纳公司的新冠疫苗可能会导致与影响过敏性哮喘和过敏性鼻炎的过敏原发生T细胞交叉反应。除了自然病毒感染外，进一步的研究应评估新冠疫苗接种对过敏性疾病严重程度和症状学的临床影响。
