Li Mingming, Yao Min, Shao Kangmei, Shen Xueyang, Ge Zhaoming, Li Yongnan
Department of Neurology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China.
Gansu Provincial Neurology Clinical Medical Research Center, Lanzhou University Second Hospital, Lanzhou, China.
Front Neurol. 2023 Jul 14;14:1211108. doi: 10.3389/fneur.2023.1211108. eCollection 2023.
Acute ischemic stroke (AIS) is the leading cause of morbidity and mortality among cerebrovascular diseases. While animal studies have suggested a correlation between cold-inducible RNA-binding protein (CIRP) serum levels and the severity and prognosis of cerebral infarction, there has been a lack of research exploring this association in humans with cerebral infarction.
A total of 148 patients diagnosed with AIS within 7 days from symptom onset were included in this study. Comprehensive information regarding the patients' basic demographics, medical history, clinical parameters, the severity of cerebral infarction, and serum CIRP levels was collected. Follow-up data were obtained through telephonic interviews or by reviewing clinical notes for 3 months after the patients were discharged to assess the functional outcomes of treatment.
The findings of this study demonstrated a significant increase in serum CIRP levels during the early stages of AIS, followed by a gradual decline after 3 days. Significant differences were observed in the serum CIRP levels between the 1-day group and the 4-7 day group ( < 0.0047), as well as between the 2-3 day group and the 4-7 day group ( < 0.0006). Moreover, a significant positive correlation was observed between the serum CIRP levels and the severity of cerebral infarction. Higher serum CIRP levels were associated with more severe National Institutes of Health Stroke Scale scores ( < 0.05) and larger cerebral infarction volumes ( < 0.05). Furthermore, patients with higher serum CIRP levels exhibited poorer modified Rankin scale scores ( < 0.05). These findings indicate that serum CIRP serves as an essential pro-inflammatory mediator and a valuable biomarker for assessing brain injury in patients with AIS.
The findings of this study suggest an elevation in serum CIRP levels among patients with AIS. These levels are positively correlated with the severity of AIS and serve as indicators of a poor prognosis. Therefore, CIRP could serve as a target for early clinical intervention while managing AIS, and further research should explore serum CIRP levels as prognostic indicators in AIS.
急性缺血性卒中（AIS）是脑血管疾病中发病和死亡的主要原因。虽然动物研究表明冷诱导RNA结合蛋白（CIRP）血清水平与脑梗死的严重程度和预后之间存在相关性，但缺乏对脑梗死患者中这种关联的研究。
本研究纳入了148例症状发作后7天内诊断为AIS的患者。收集了患者的基本人口统计学信息、病史、临床参数、脑梗死严重程度和血清CIRP水平等综合信息。通过电话访谈或在患者出院后3个月查阅临床记录获得随访数据，以评估治疗的功能结局。
本研究结果表明，AIS早期血清CIRP水平显著升高，3天后逐渐下降。1天组与4 - 7天组之间的血清CIRP水平存在显著差异（<0.0047），2 - 3天组与4 - 7天组之间也存在显著差异（<0.0006）。此外，血清CIRP水平与脑梗死严重程度之间存在显著正相关。血清CIRP水平越高，美国国立卫生研究院卒中量表评分越高（<0.05），脑梗死体积越大（<0.05）。此外，血清CIRP水平较高的患者改良Rankin量表评分较差（<0.05）。这些发现表明，血清CIRP是评估AIS患者脑损伤的重要促炎介质和有价值的生物标志物。
本研究结果表明AIS患者血清CIRP水平升高。这些水平与AIS的严重程度呈正相关，是预后不良的指标。因此，CIRP可作为AIS治疗中早期临床干预的靶点，进一步的研究应探索血清CIRP水平作为AIS的预后指标。
