Lederman H M, Roifman C M, Lavi S, Gelfand E W
Am J Med. 1986 Sep;81(3):443-6. doi: 10.1016/0002-9343(86)90296-2.
Severe adverse reactions to intravenous immune serum globulin occurred repeatedly in four of 10 hypogammaglobulinemic patients. Treatment-limiting symptoms included fever, chills, headache, hypertension, and chest pain. Pretreatment of patients with hydrocortisone immediately prior to infusion prevented subsequent adverse reactions and permitted these patients to receive immune serum globulin intravenously.
10例低丙种球蛋白血症患者中有4例反复出现静脉注射免疫血清球蛋白的严重不良反应。限制治疗的症状包括发热、寒战、头痛、高血压和胸痛。在输注前立即用氢化可的松对患者进行预处理可预防随后的不良反应，并使这些患者能够静脉接受免疫血清球蛋白治疗。
