Day N K, Good R A, Wahn V
Am J Med. 1984 Mar 30;76(3A):25-32. doi: 10.1016/0002-9343(84)90316-4.
Fifteen patients with hypogammaglobulinemia or agammaglobulinemia were treated with intravenous gamma globulin preparation over a 17-month period. The patients were selected for treatment if they had chronic antibody deficiency syndromes associated with increased susceptibility to infections. Levels of circulating immune complexes, C1q, C3, and C3d were determined in serum samples obtained before treatment and immediately following treatment with the gamma globulin. In every patient studied, circulating immune complexes were detectable in the postinfusion samples. Two patients had adverse reactions to the intravenous gamma globulin therapy. Analysis of the serum samples of both of these patients showed that one patient had an autoantibody to IgA and the other had an autoantibody to beta-lipoprotein. Both IgA and beta-lipoprotein were present in the intravenous gamma globulin preparations. Therefore, reaction with each of the autoantibodies by the antigens activated the complement system in vivo with production of split products of C3.
在17个月的时间里，对15例低丙种球蛋白血症或无丙种球蛋白血症患者进行了静脉注射丙种球蛋白制剂治疗。如果患者患有与感染易感性增加相关的慢性抗体缺乏综合征，则选择他们进行治疗。在用丙种球蛋白治疗前和治疗后立即采集的血清样本中，测定循环免疫复合物、C1q、C3和C3d的水平。在每例研究患者中，输注后样本中均可检测到循环免疫复合物。两名患者对静脉注射丙种球蛋白治疗有不良反应。对这两名患者的血清样本分析表明，一名患者有抗IgA自身抗体，另一名患者有抗β-脂蛋白自身抗体。IgA和β-脂蛋白均存在于静脉注射丙种球蛋白制剂中。因此，抗原与每种自身抗体的反应在体内激活了补体系统，产生了C3裂解产物。
