3D 打印晶格启发复合材料用于骨重建。

3D-Printed lattice-inspired composites for bone reconstruction.

机构信息

Mechanical and Energy Engineering College, Shaoyang University, Shaoyang 422000, Hunan, China.

Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Biology & Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou 215006, Jiangsu, China.

出版信息

J Mater Chem B. 2023 Aug 9;11(31):7353-7363. doi: 10.1039/d3tb01053h.

DOI:10.1039/d3tb01053h

PMID:37522170

Abstract

Mechanical performance is crucial for biomedical applications of scaffolds. In this study, the stress distribution of six lattice-inspired structures was investigated using finite element simulations, and scaffolds with pre-designed structures were prepared using selective laser sintering (SLS) technology. The results showed that scaffolds with face-centered cubic (FCC) structures exhibited the highest compressive strength. Moreover, scaffolds composed of polylactic acid/anhydrous calcium hydrogen phosphate (PLA/DCPA) showed good mechanical properties and bioactivity. An study showed that these scaffolds promoted cell proliferation significantly and showed excellent osteogenic performance. Composite scaffolds with FCC structures are promising for bone tissue engineering.

摘要

机械性能对于支架的生物医学应用至关重要。在这项研究中，使用有限元模拟研究了六种晶格启发结构的应力分布，并使用选择性激光烧结（SLS）技术制备了具有预设计结构的支架。结果表明，具有面心立方（FCC）结构的支架表现出最高的抗压强度。此外，由聚乳酸/无水磷酸氢钙（PLA/DCPA）组成的支架具有良好的机械性能和生物活性。一项研究表明，这些支架可显著促进细胞增殖，并表现出优异的成骨性能。具有 FCC 结构的复合支架有望用于骨组织工程。