Department of Life Sciences, University of Bath, Bath, UK.
School of Psychology and Neuroscience@Nottingham, University of Nottingham, Nottingham, UK.
J Psychopharmacol. 2023 Nov;37(11):1051-1057. doi: 10.1177/02698811231182607. Epub 2023 Jul 31.
Animal models are important in preclinical psychopharmacology to study mechanisms and potential treatments for psychiatric disorders. A working group of 14 volunteers, comprising an international team of researchers from academia and industry, convened in 2021 to discuss how to improve the translational relevance and interpretation of findings from animal models that are used in preclinical psychopharmacology. The following paper distils the outcomes of the working group's discussions into 10 key considerations for the planning and reporting of behavioural studies in animal models relevant to psychiatric disorders. These form the iTRIPP guidelines (Improving Translational Relevance In Preclinical Psychopharmacology). These guidelines reflect the key considerations that the group thinks will likely have substantial impact in terms of improving the translational relevance of behavioural studies in animal models that are used to study psychiatric disorders and their treatment. They are relevant to the research community when drafting and reviewing manuscripts, presentations and grant applications. The iTRIPP guidelines are intended to complement general recommendations for planning and reporting animal studies that have been published elsewhere, by enabling researchers to fully consider the most appropriate animal model for the research purpose and to interpret their findings appropriately. This in turn will increase the clinical benefit of such research and is therefore important not only for the scientific community but also for patients and the lay public.
动物模型在临床前精神药理学中很重要，可用于研究精神障碍的机制和潜在治疗方法。一个由 14 名志愿者组成的工作组，由学术界和工业界的国际研究团队组成，于 2021 年召开会议，讨论如何提高用于临床前精神药理学的动物模型研究结果的转化相关性和解释。本文将工作组讨论的结果提炼成与精神障碍相关的动物模型行为研究规划和报告的 10 项关键考虑因素。这些构成了 iTRIPP 指南（改善临床前精神药理学中的转化相关性）。这些指南反映了工作组认为在提高用于研究精神障碍及其治疗的动物模型中行为研究的转化相关性方面可能具有重大影响的关键考虑因素。在起草和审查手稿、演示文稿和资助申请时，这些指南与研究界相关。iTRIPP 指南旨在补充其他地方发表的关于规划和报告动物研究的一般建议，使研究人员能够充分考虑最适合研究目的的动物模型，并适当解释他们的发现。这反过来将增加此类研究的临床效益，因此不仅对科学界，而且对患者和普通公众都很重要。
