Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Department of Neurology, West China Hospital of Sichuan University, Sichuan, China.
J Parkinsons Dis. 2023;13(6):1061-1071. doi: 10.3233/JPD-230060.
Nocturnal symptoms have a significant effect on the quality of life in Parkinson's disease (PD) patients.
This study aimed to investigate the prevalence and associated factors of nocturnal symptoms in Chinese PD patients.
This multicenter cross-sectional study included 1,500 patients with primary PD from 18 centers in China was carried out between February 2019 and February 2020. Questionnaires including Parkinson's disease sleep scale 2 (PDSS-2), Parkinson's disease questionnaire 8 (PDQ-8), Beck depression inventory (BDI), and generalized anxiety disorder scale 7 (GAD-7) were used to assess nocturnal symptoms, quality of life, depression, and anxiety.
Among 1,500 Chinese PD patients, 576 (38.4%) reported nocturnal symptoms. Of them, 59.2% were older than 65 years. The PDQ-8 total score was higher in patients with nocturnal symptoms (p < 0.01). Moderate and severe depression was reported more often in patients with nocturnal symptoms (p < 0.01), and the occurrence and severity of anxiety were higher as well (p < 0.01). Longer disease duration and higher Hoehn-Yahr (HY) stage were independently associated with nocturnal symptoms (p < 0.01). Education level, depression, disease course, HY stage, and nocturnal symptoms were related to the quality of life in Chinese PD patients (p < 0.01).
Our study found that 38.4% of Chinese PD patients have nocturnal symptoms, even in early and mid-stage PD. Nocturnal symptoms were associated with worse quality of life and higher incidences of depression and anxiety. Nocturnal symptoms should be included in the assessment and care plan, especially in patients with longer disease courses and higher HY stages.
夜间症状对帕金森病（PD）患者的生活质量有重大影响。
本研究旨在调查中国 PD 患者夜间症状的患病率及相关因素。
本多中心横断面研究纳入了来自中国 18 个中心的 1500 名原发性 PD 患者，于 2019 年 2 月至 2020 年 2 月进行。使用帕金森病睡眠量表 2（PDSS-2）、帕金森病问卷 8（PDQ-8）、贝克抑郁量表（BDI）和广泛性焦虑症量表 7（GAD-7）评估夜间症状、生活质量、抑郁和焦虑。
在 1500 名中国 PD 患者中，576 名（38.4%）报告有夜间症状。其中，59.2%的患者年龄大于 65 岁。夜间症状患者的 PDQ-8 总分较高（p<0.01）。夜间症状患者中度和重度抑郁的报告更为常见（p<0.01），焦虑的发生和严重程度也更高（p<0.01）。较长的病程和较高的 Hoehn-Yahr（HY）分期与夜间症状独立相关（p<0.01）。教育程度、抑郁、病程、HY 分期和夜间症状与中国 PD 患者的生活质量相关（p<0.01）。
本研究发现，38.4%的中国 PD 患者存在夜间症状，即使在早期和中期 PD 中也是如此。夜间症状与生活质量更差、抑郁和焦虑发生率更高相关。夜间症状应纳入评估和护理计划，尤其是在病程较长和 HY 分期较高的患者中。
