School of Chemical Sciences, Indian Institute of Technology Mandi, Mandi-175001, Himachal Pradesh, India.
School of Biosciences and Bioengineering, Indian Institute of Technology Mandi, Mandi-175001, Himachal Pradesh, India.
Org Biomol Chem. 2023 Aug 9;21(31):6263-6288. doi: 10.1039/d3ob00444a.
Considering that carbon monoxide is both a vital gasotransmitter and an obnoxious gas, tremendous efforts have been dedicated toward its recognition through various methods. However, the fluorescent light-up approach through the exploration of optical markers remains one of the most convenient methods owing to its several advantages. Amongst the different approaches towards the development of CO responsive optically active molecular markers, the Tsuji-Trost reaction-based CO recognition strategy has remained one of the most significant areas of interest across researchers working in this field. However, there have been no attempts to exclusively summarize the commendable work done in this area yet. The current review, therefore, attempts to summarize the developments of various optical probes following this reaction strategy until the year 2022. This review provides detailed mechanistic insights into the Tsuji-Trost mediated CO detection strategy. Besides, discussions on the strategic development and employment of probes based on various allyl derivatives - allyl carbamate/carbonate/ethers - will provide a thorough understanding of the detection method. The significant advancements of the Tsuji-Trost reaction as an interesting strategy that is accepted and extensively explored for monitoring CO in various media including air, aqueous solutions and living systems have been elaborately discussed. Various potential applications and utilization of these developed fluorogenic probes for tracing CO in different living systems have been examined systematically. Moreover, monitoring of exogenous/endogenous CO levels, modulation of intracellular CO concentration under various induced conditions and bioimaging of CO in models have also been detailed here. Briefly, this review summarizes the current prospects of this detection method and the future directions in related fields.
鉴于一氧化碳既是一种重要的气体递质，又是一种令人讨厌的气体，人们已经投入了巨大的努力来通过各种方法对其进行识别。然而，由于其诸多优点，通过光学标记物的荧光点亮方法仍然是最方便的方法之一。在开发 CO 响应光学活性分子标记物的不同方法中，基于 Tsuji-Trost 反应的 CO 识别策略一直是该领域研究人员最感兴趣的领域之一。然而，迄今为止，还没有人试图专门总结该领域所做的令人称赞的工作。因此，本综述试图总结截至 2022 年，该反应策略下各种光学探针的发展情况。本综述提供了有关 Tsuji-Trost 介导的 CO 检测策略的详细机理见解。此外，关于基于各种烯丙基衍生物（烯丙基氨基甲酸酯/碳酸盐/醚）的探针的战略发展和应用的讨论将提供对检测方法的透彻理解。还详细讨论了 Tsuji-Trost 反应作为一种有趣的策略的重大进展，该策略已被接受并广泛用于监测包括空气、水溶液和活系统在内的各种介质中的 CO。系统地检查了这些开发的荧光探针在不同活系统中追踪 CO 的各种潜在应用和利用。此外，还详细研究了在各种诱导条件下监测外源性/内源性 CO 水平、调节细胞内 CO 浓度以及在模型中进行 CO 生物成像的情况。简而言之，本综述总结了该检测方法的当前前景和相关领域的未来方向。
