Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou, China.
Department of Pathology, Hangzhou Third People's Hospital, Hangzhou, China.
Skin Res Technol. 2023 Jul;29(7):e13416. doi: 10.1111/srt.13416.
Acquired perforating dermatosis (APD) is a rare skin condition characterized by degenerated materials eliminated from the dermis. Several retrospective studies on APD have been reported; however, few data are available on Chinese APD and their features on dermoscopy and reflective confocal microscope (RCM) assays.
The aim of this study was to retrospectively evaluate the clinical and histopathologic data of 37 acquired perforating dermatosis cases, and assess their features on dermoscopy and RCM.
Thirty-seven APD patients were retrospectively enrolled in our study. We characterized the clinical histopathological features, concomitant diseases, treatment responses, and the dermoscopy and RCM findings.
Pruritus was the most common symptom, with the lower extremities as the most predilection sites (86.5%, n = 32; 91.9%, n = 34, respectively). Concomitant diseases were found in 34 patients (92.6%), among which diabetes mellitus was the most common, followed by thyroid nodules, allergic dermatosis, and chronic renal insufficiency. Dermoscopy and RCM assays were performed in 11 patients. The typical RCM images were hyperreflective cord-like structures from the epidermis to dermis. Dermoscopy features of fully developed lesions showed central ulceration with peripheral hairpin-like or loop-like capillaries with characteristic garland arrangements.
APD is an uncommon skin disorder associated with various systemic conditions in Chinese individuals. Thyroid disorders are an overlooked complication and may play an important role in the development of APD. The results of this study indicate that noninvasive dermoscopy and RCM examination are helpful in the rapid diagnosis and early intervention of APD.
获得性穿孔性皮肤病（APD）是一种罕见的皮肤疾病，其特征为真皮中排出的变性物质。已有几项关于 APD 的回顾性研究报告，但关于中国 APD 及其在皮肤镜和反射共聚焦显微镜（RCM）检查中的特征的数据较少。
本研究旨在回顾性评估 37 例获得性穿孔性皮肤病患者的临床和组织病理学数据，并评估其皮肤镜和 RCM 特征。
回顾性纳入 37 例 APD 患者。我们描述了临床组织病理学特征、伴随疾病、治疗反应以及皮肤镜和 RCM 结果。
瘙痒是最常见的症状，以下肢最常见（86.5%，n=32；91.9%，n=34）。34 例患者存在伴随疾病（92.6%），其中糖尿病最常见，其次是甲状腺结节、过敏性皮肤病和慢性肾功能不全。11 例患者进行了皮肤镜和 RCM 检查。典型的 RCM 图像为从表皮到真皮的高反射线状结构。完全发育病变的皮肤镜特征为中央溃疡，周围有发夹状或环形毛细血管，具有特征性的花环排列。
APD 是一种在中国人群中与各种系统性疾病相关的罕见皮肤病。甲状腺疾病是一种被忽视的并发症，可能在 APD 的发生中起重要作用。本研究结果表明，非侵入性皮肤镜和 RCM 检查有助于快速诊断和早期干预 APD。
