Samarut Jacques, Plateroti Michelina
Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Université de Lyon, Hospices Civils de Lyon, Lyon, France.
Département de la Recherche, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, INSERM U1052, CNRS UMR5286, Université de Lyon, Université Lyon 1, Lyon, France.
Methods Mol Biol. 2018;1801:1-8. doi: 10.1007/978-1-4939-7902-8_1.
Thyroid hormone receptors (TRs) were cloned based on their homology with the retroviral oncogene v-ERBA. In Vertebrates two genes, THRA and THRB, encode respectively many isotypes and isoforms of receptors TRα and TRβ, resulting from alternative splicing and/or internal transcription start sites. We present here a wide overview of this diversity and of their mechanisms of action as transcription regulators, as well as alternative actions through cytoplasmic signaling.
甲状腺激素受体（TRs）是根据它们与逆转录病毒癌基因v-ERBA的同源性克隆出来的。在脊椎动物中，THRA和THRB这两个基因分别编码受体TRα和TRβ的许多同种型和亚型，这些同种型和亚型是由可变剪接和/或内部转录起始位点产生的。我们在此全面概述这种多样性及其作为转录调节因子的作用机制，以及通过细胞质信号传导的其他作用。
