Department of Gastroenterology, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, China.
Eur Rev Med Pharmacol Sci. 2023 Jul;27(14):6736-6743. doi: 10.26355/eurrev_202307_33144.
The effect of probiotics supplementation on the gut microbiota in Helicobacter pylori (H. pylori) eradication therapy is controversial. Therefore, this review aimed to illustrate changes in the gut microbiota after standard eradication therapy with probiotics supplements.
A computerized literature search in PubMed, Cochrane Library, Web of Science, and Embase database was performed up to February 1st, 2022, with English language restriction. The extracted outcomes were analyzed, including gut microbiota, adverse effects, and eradication rate.
13 studies reported data on 777 participants who were finally eligible for this systematic review. All of them are randomized controlled trials investigating the effect of H. pylori eradication with probiotics supplementation therapy on gut microbiota. Probiotics supplementation seems to play a positive role in restoring the gut microbiota during H. pylori eradication therapy. However, the changes in the gut microbiota are still controversial. The included studies had significant heterogeneity in the study population, diagnostic methods of H. pylori infection, and detection techniques of the gut microbiota and probiotics species.
The results provided a basis for the rational selection of probiotics in the H. pylori eradication process. Probiotic supplementation might keep the balance of gut microbiota and reduce the gastrointestinal adverse effects of antibiotics, but whether it could improve the eradication rate or not is a debatable point. Therefore, more research is needed to provide evidence.
益生菌补充剂对幽门螺杆菌（H. pylori）根除治疗中肠道微生物群的影响存在争议。因此，本综述旨在说明在标准根除治疗中添加益生菌补充剂后肠道微生物群的变化。
对 PubMed、Cochrane 图书馆、Web of Science 和 Embase 数据库进行了计算机检索，检索时间截至 2022 年 2 月 1 日，语言限制为英语。分析提取的结果，包括肠道微生物群、不良反应和根除率。
13 项研究报告了 777 名参与者的数据，这些参与者最终符合本系统综述的纳入标准。所有研究均为随机对照试验，旨在调查益生菌补充剂辅助 H. pylori 根除治疗对肠道微生物群的影响。益生菌补充剂似乎在 H. pylori 根除治疗期间恢复肠道微生物群方面发挥了积极作用。然而，肠道微生物群的变化仍存在争议。纳入的研究在研究人群、H. pylori 感染的诊断方法以及肠道微生物群和益生菌种类的检测技术方面存在显著异质性。
这些结果为 H. pylori 根除过程中合理选择益生菌提供了依据。益生菌补充剂可能有助于维持肠道微生物群的平衡，并减少抗生素引起的胃肠道不良反应，但它是否能提高根除率仍存在争议。因此，需要更多的研究来提供证据。
