Tim-3 在 COVID-19 中的作用：一个有潜力的生物标志物和治疗靶点。
Role of Tim-3 in COVID-19: a potential biomarker and therapeutic target.
机构信息
Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, 450001, Zhengzhou, Henan, China.
Department of Urology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, 450003, Zhengzhou, Henan, China.
出版信息
Arch Virol. 2023 Jul 31;168(8):213. doi: 10.1007/s00705-023-05842-2.
T cell immunoglobulin and mucin domain containing protein 3 (Tim-3), an immune checkpoint, is important for maintaining immune tolerance. There is increasing evidence that Tim-3 is aberrantly expressed in patients with COVID-19, indicating that it may play an important role in COVID-19. In this review, we discuss the altered expression and potential role of Tim-3 in COVID-19. The expression of Tim-3 and its soluble form (sTim-3) has been found to be upregulated in COVID-19 patients. The levels of Tim-3 on T cells and circulating sTim-3 have been shown to be associated with the severity of COVID-19, suggesting that this protein could be a potential biomarker of COVID-19. Moreover, this review also highlights the potential of Tim-3 as a therapeutic target of COVID-19.
T 细胞免疫球蛋白和粘蛋白结构域蛋白 3（Tim-3）是一种免疫检查点，对于维持免疫耐受非常重要。越来越多的证据表明，Tim-3 在 COVID-19 患者中异常表达，表明它可能在 COVID-19 中发挥重要作用。在这篇综述中，我们讨论了 Tim-3 在 COVID-19 中的改变表达和潜在作用。已经发现 Tim-3 及其可溶性形式（sTim-3）在 COVID-19 患者中的表达上调。T 细胞上的 Tim-3 水平和循环中的 sTim-3 水平与 COVID-19 的严重程度相关，表明该蛋白可能是 COVID-19 的潜在生物标志物。此外，本综述还强调了 Tim-3 作为 COVID-19 治疗靶点的潜力。
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