Liu Zhenrong, Wang Zhiqiang, Liao Haiyan, Li Zheng
College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, P. R. China.
Org Lett. 2023 Aug 11;25(31):5812-5816. doi: 10.1021/acs.orglett.3c02069. Epub 2023 Jul 31.
An efficient method for the construction of 1,2,3-triarylindoles through one-pot multicomponent reactions using calcium carbide, 3 mol of iodoarenes, and aromatic amines as starting materials was described. A series of target products were obtained by the simultaneous formation of five bonds in one step. The main advantages for this protocol are the use of a convenient alkyne source, wide scope of substrates, and simple workup procedure. The method can be extended to the gram scale.
描述了一种以碳化钙、3摩尔碘代芳烃和芳香胺为起始原料，通过一锅多组分反应构建1,2,3-三芳基吲哚的有效方法。通过一步同时形成五个键获得了一系列目标产物。该方法的主要优点是使用了方便的炔烃源、底物范围广以及后处理程序简单。该方法可扩展至克级规模。
