Department of Psychiatry, Otto-von-Guericke University, Leipziger Str. 44, D-39120 Magdeburg, Germany.
Leibniz Institute for Neurobiology, RG Neuroplasticity, D-39118 Magdeburg, Germany; Institute for Pharmacology and Toxicology, Otto-von-Guericke University, Magdeburg, Germany, Center for Behavioral Brain Sciences, Magdeburg, Germany.
J Chem Neuroanat. 2023 Oct;132:102321. doi: 10.1016/j.jchemneu.2023.102321. Epub 2023 Jul 29.
Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are nearly ubiquitously expressed. They are localized in mitochondria, cytosol and cell nuclei. In the healthy CNS, they occur in neurons and non-neuronal cells (oligodendrocytes, astrocytes, microglia, and endothelial cells) and fulfill pivotal functions in brain development and aging, the regulation of brain metabolism, maintenance of structural integrity, synapse formation, aminoacidergic neurotransmission and, probably, regulation of brain action of certain hypothalamic-pituitary hormones.With regard to the diseased brain there is increasing evidence that prohibitins are prominently involved in numerous major diseases of the CNS, which are summarized and discussed in the present review (brain tumors, neurotropic viruses, Alzheimer disease, Down syndrome, Fronto-temporal and vascular dementia, dementia with Lewy bodies, Parkinson disease, Huntington disease, Multiple sclerosis, Amyotrophic lateral sclerosis, stroke, alcohol use disorder, schizophrenia and autism). Unfortunately, there is no PHB-targeted therapy available for any of these diseases.
抑制素 1（PHB1）和抑制素 2（PHB2）是几乎普遍表达的蛋白质。它们定位于线粒体、细胞质和细胞核中。在健康的中枢神经系统中，它们存在于神经元和非神经元细胞（少突胶质细胞、星形胶质细胞、小胶质细胞和内皮细胞）中，并在大脑发育和衰老、脑代谢调节、结构完整性维持、突触形成、氨基酸能神经传递以及可能调节某些下丘脑-垂体激素对大脑的作用方面发挥关键作用。关于患病大脑，越来越多的证据表明，抑制素在中枢神经系统的许多主要疾病中都有突出的参与，本综述对这些疾病进行了总结和讨论（脑肿瘤、神经病毒、阿尔茨海默病、唐氏综合征、额颞痴呆和血管性痴呆、路易体痴呆、帕金森病、亨廷顿病、多发性硬化症、肌萎缩侧索硬化症、中风、酒精使用障碍、精神分裂症和自闭症）。不幸的是，对于这些疾病中的任何一种，都没有针对 PHB 的靶向治疗方法。
