prohibitin蛋白：在多种功能中发挥的新作用
The Prohibitins: emerging roles in diverse functions.
作者信息
Mishra Suresh, Murphy Leigh C, Murphy Liam J
机构信息
Department of Physiology, University of Manitoba, Winnipeg, Canada.
出版信息
J Cell Mol Med. 2006 Apr-Jun;10(2):353-63. doi: 10.1111/j.1582-4934.2006.tb00404.x.
The prohibitins, Phb1 and Phb2 are highly conserved proteins in eukaryotic cells that are present in multiple cellular compartments. Initial investigations focused on the role of Phb1 as an inhibitor of cell proliferation hence the original name prohibitin. However both proteins appear to have a diverse range of functions and recent evidence suggests that the prohibitins have very similar but as yet only partially understood functions. In addition to their role as chaperone proteins in the mitochondria, and their ability to target to lipid rafts, their is now compelling evidence that both prohibitins are localized in the nucleus and can modulate transcriptional activity by interacting with various transcription factors, including the steroid hormone receptors, either directly or indirectly. In addition Phb1 and Phb2 are present in the circulation and can be internalized when added to cultured cells suggesting that the circulating prohibitins may have some regulatory role. This review presents some of the recent developments in prohibitin research and focuses on the similarities in the structure and function of these interesting proteins.
禁止素（Phb1）和Phb2是真核细胞中高度保守的蛋白质，存在于多个细胞区室中。最初的研究集中于Phb1作为细胞增殖抑制剂的作用，因此其最初的名称为禁止素。然而，这两种蛋白质似乎具有多种功能，最近的证据表明，禁止素具有非常相似但尚未完全了解的功能。除了作为线粒体中的伴侣蛋白以及靶向脂筏的能力外，现在有令人信服的证据表明，这两种禁止素都定位于细胞核中，并且可以通过直接或间接与包括类固醇激素受体在内的各种转录因子相互作用来调节转录活性。此外，Phb1和Phb2存在于循环系统中，当添加到培养细胞中时可以被内化，这表明循环中的禁止素可能具有一些调节作用。本综述介绍了禁止素研究的一些最新进展，并重点关注这些有趣蛋白质在结构和功能上的相似性。
Zotero 插件