Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia; Ural Federal University, Ekaterinburg, Russia.
National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
Behav Brain Res. 2023 Sep 13;453:114607. doi: 10.1016/j.bbr.2023.114607. Epub 2023 Jul 29.
Delirium is an acute neuropsychiatric condition characterized by impaired behavior and cognition. Although the syndrome has been known for millennia, its CNS mechanisms and risk factors remain poorly understood. Experimental animal models, especially rodent-based, are commonly used to probe various pathogenetic aspects of delirium. Complementing rodents, the zebrafish (Danio rerio) emerges as a promising novel model organism to study delirium. Zebrafish demonstrate high genetic and physiological homology to mammals, easy maintenance, robust behaviors in various sensitive behavioral tests, and the potential to screen for pharmacological agents relevant to delirium. Here, we critically discuss recent developments in the field, and emphasize the developing utility of zebrafish models for translational studies of delirium and deliriant drugs. Overall, the zebrafish represents a valuable and promising aquatic model species whose use may help understand delirium etiology, as well as develop novel therapies for this severely debilitating disorder.
谵妄是一种以行为和认知障碍为特征的急性神经精神疾病。尽管该综合征已存在了数千年，但人们对其中枢神经系统机制和风险因素仍知之甚少。实验动物模型，特别是基于啮齿类动物的模型，通常被用于探究谵妄的各种发病机制。除了啮齿类动物，斑马鱼（Danio rerio）也成为了研究谵妄的一种很有前途的新型模式生物。斑马鱼与哺乳动物在遗传和生理上具有高度同源性，易于饲养，在各种敏感行为测试中表现出强健的行为，并且有潜力筛选出与谵妄相关的药物。在这里，我们批判性地讨论了该领域的最新进展，并强调了斑马鱼模型在谵妄和致幻药物的转化研究中的发展应用。总的来说，斑马鱼是一种有价值且有前途的水生模式生物，其应用可能有助于了解谵妄的病因，并为这种严重致残的疾病开发新的治疗方法。
