Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.
Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
Neurosci Biobehav Rev. 2019 Oct;105:126-133. doi: 10.1016/j.neubiorev.2019.07.017. Epub 2019 Jul 29.
Schizophrenia is a severely debilitating, lifelong psychiatric disorder affecting approximately 1% of global population. The pathobiology of schizophrenia remains poorly understood, necessitating further translational research in this field. Experimental (animal) models are becoming indispensable for studying schizophrenia-related phenotypes and pro/antipsychotic drugs. Mounting evidence suggests the zebrafish (Danio rerio) as a useful tool to model various phenotypes relevant to schizophrenia. In addition to their complex robust behaviors, zebrafish possess high genetic and physiological homology to humans, and are also sensitive to drugs known to reduce or promote schizophrenia clinically. Here, we summarize findings on zebrafish application to modeling schizophrenia, as well as discuss recent progress and remaining challenges in this field. We also emphasize the need in further development and wider use of zebrafish models for schizophrenia to better understand its pathogenesis and enhance the search for new effective antipsychotics.
精神分裂症是一种严重致残的终身精神疾病，影响着全球约 1%的人口。精神分裂症的发病机制仍不清楚，这就需要在该领域进行更多的转化研究。实验（动物）模型对于研究与精神分裂症相关的表型和抗精神病药物变得不可或缺。越来越多的证据表明，斑马鱼（Danio rerio）是一种有用的工具，可以模拟与精神分裂症相关的各种表型。除了它们复杂而稳健的行为外，斑马鱼与人类在遗传和生理上高度同源，并且对临床上已知的能减少或促进精神分裂症的药物也很敏感。在这里，我们总结了斑马鱼在模拟精神分裂症方面的应用，并讨论了该领域的最新进展和仍然存在的挑战。我们还强调需要进一步开发和更广泛地使用斑马鱼模型来更好地理解其发病机制，并增强对新的有效抗精神病药物的寻找。
