Soronzonbold Angar, Munkhkherlen Erkhbilguun, Batchuluun Khongorzul, Puntsag Oyun-Enkh, Shuumarjav Uurtuya, Batbayar Bayarchimeg
School of Dentistry, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
Department of Histology, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
J Periodontal Implant Sci. 2024 Feb;54(1):37-43. doi: 10.5051/jpis.2204360218. Epub 2023 Jun 12.
The inflammatory response due to inflammatory cytokines, bacterial pathogens, and the altered lipoprotein metabolism in patients with periodontitis indicates that infection with periodontal anaerobic bacteria may influence atherogenesis and . We aimed to explore the effect of periodontitis concerning clinical and ultrasound markers of early atherosclerosis.
In this case-control study, a total of 30 systemically healthy adults (15 with periodontitis and 15 without periodontitis) over 40 years of age were studied. Periodontitis was determined by measuring the clinical attachment level (CAL) and radiographic bone loss (RBL). Conventional cardiovascular risk factors, including body mass index, serum levels of total cholesterol (TCH), triglycerides (TG), and high-density and low-density lipoprotein (HDL and LDL, respectively) cholesterol were evaluated. Carotid artery intima-media thickness (IMT) was measured using ultrasonography.
The mean values of the CAL and carotid IMT were 5.02±0.9 mm and 0.084±0.01 cm vs. 1.6±0.61 mm and 0.072±0.02 cm in the periodontitis and healthy groups, respectively, reflecting statistically significant differences (=0.001 and =0.037, respectively). There were statistically significant differences in the serum levels of TCH, TG, and LDL between the 2 groups (=0.017). The CAL and RBL were positively associated with carotid IMT and serum cholesterol levels, except for HDL, whereas tooth loss was not associated with any markers (<0.05). Compared to the healthy group, participants with periodontitis exhibited 2.09 times higher odds (95% confidence interval, 1.22-3.59) of having subclinical atherosclerosis.
The presence of periodontitis increased the risk of atherosclerosis.
牙周炎患者因炎性细胞因子、细菌病原体及脂蛋白代谢改变而产生的炎症反应表明，牙周厌氧菌感染可能影响动脉粥样硬化的发生。我们旨在探讨牙周炎对早期动脉粥样硬化临床及超声标志物的影响。
在这项病例对照研究中，共纳入了30名40岁以上的全身健康成年人（15名患有牙周炎，15名未患牙周炎）。通过测量临床附着水平（CAL）和影像学骨丧失（RBL）来确定牙周炎。评估了包括体重指数、血清总胆固醇（TCH）、甘油三酯（TG）以及高密度和低密度脂蛋白（分别为HDL和LDL）胆固醇水平等传统心血管危险因素。使用超声测量颈动脉内膜中层厚度（IMT）。
牙周炎组和健康组的CAL平均值分别为5.02±0.9mm和1.6±0.61mm，颈动脉IMT平均值分别为0.084±0.01cm和0.072±0.02cm，差异具有统计学意义（分别为=0.001和=0.037）。两组之间血清TCH、TG和LDL水平存在统计学显著差异（=0.017）。除HDL外，CAL和RBL与颈动脉IMT及血清胆固醇水平呈正相关，而牙齿缺失与任何标志物均无关联（<0.05）。与健康组相比，患有牙周炎的参与者发生亚临床动脉粥样硬化的几率高2.09倍（95%置信区间，1.22 - 3.59）。
牙周炎的存在增加了动脉粥样硬化的风险。
