School of Public Health, Fujian Medical University, Fujian, China.
School of Public Health, Fujian Medical University, Fujian, China.
Nutr Metab Cardiovasc Dis. 2023 Oct;33(10):1969-1980. doi: 10.1016/j.numecd.2023.06.001. Epub 2023 Jun 8.
BACKGROUND & AIMS: Although hyperuricemia is a known risk factor for coronary heart disease (CHD), little is known about the role of blood pressure in mediating this association. The purpose of this study is to investigate the role of blood pressure-related indicators and Thrombospondin 3 (THBS3) in the association between hyperuricemia and CHD.
Our observational epidemiology study included 593 CHD cases and 760 controls from a residential stable sample. We also chose 43 new CHD patients and 43 controls to test the expression levels of THBS3 using ELISA kits. We used logistic regression models and mediating effect analysis to investigate the relationships between hyperuricemia and CHD, as well as the mediating role of blood pressure-related indicators and THBS3. In the general population (OR: 2.001 [95% CI: 1.528-2.622]), male population (OR: 1.591 [95% CI: 1.119-2.262]), and female population (OR: 2.813 [95% CI: 1.836-4.310]), hyperuricemia is an independent risk factor for CHD. In general, average systolic blood pressure (SBP) and average pulse pressure difference (PPD) mediated 3.35% and 4.59%, respectively, of the association between hyperuricemia and CHD, and 6.60% and 6.60% in women. However, in the male population, we have not yet found that blood pressure-related indicators had a significant mediating effect. Meanwhile, we found that THBS3 mediated 19.23% of the association between hyperuricemia and CHD.
Average SBP, PPD, and THBS3 all play a role in the association of hyperuricemia and CHD. In the female population, similar mediating results in blood pressure-related indicators were observed.
尽管高尿酸血症是冠心病（CHD）的已知危险因素，但人们对血压在介导这种关联中的作用知之甚少。本研究旨在探讨与血压相关的指标和血小板反应蛋白 3（THBS3）在高尿酸血症与 CHD 之间的关联中的作用。
我们的观察性流行病学研究包括来自居住稳定样本的 593 例 CHD 病例和 760 例对照，还选择了 43 例新的 CHD 患者和 43 例对照，使用 ELISA 试剂盒检测 THBS3 的表达水平。我们使用逻辑回归模型和中介效应分析来研究高尿酸血症与 CHD 之间的关系，以及与血压相关的指标和 THBS3 的中介作用。在一般人群（OR：2.001[95%CI：1.528-2.622]）、男性人群（OR：1.591[95%CI：1.119-2.262]）和女性人群（OR：2.813[95%CI：1.836-4.310]）中，高尿酸血症是 CHD 的独立危险因素。一般来说，平均收缩压（SBP）和平均脉压差（PPD）分别介导了高尿酸血症与 CHD 之间关联的 3.35%和 4.59%，而女性则分别为 6.60%和 6.60%。然而，在男性人群中，我们尚未发现与血压相关的指标具有显著的中介作用。同时，我们发现 THBS3 介导了高尿酸血症与 CHD 之间关联的 19.23%。
平均 SBP、PPD 和 THBS3 均在高尿酸血症与 CHD 的关联中起作用。在女性人群中，观察到与血压相关的指标具有相似的中介作用。
