Peng Hewei, Han Ying, Huang Jingru, Qiu Wenxin, Chang Huajing, Fang Jiangwang, Peng Xian-E
Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Xuefu North Road 1st, Shangjie Town, Minhou Country, Fuzhou, Fujian, China.
Department of Geriatrics, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
BMC Public Health. 2025 Jan 20;25(1):234. doi: 10.1186/s12889-025-21419-x.
The oxidative balance score (OBS) is a composite metric highlights pro-oxidants and antioxidants balance, representing the overall burden of oxidative stress. This study aims to examine the association between OBS and hyperuricemia in a Chinese population.
This study was based on population-based cross-sectional survey data of Fujian province from August 2020 to April 2021. OBS was determined based on 10 food and lifestyle OBS components. The association between OBS and hyperuricemia was investigated using logistic regression analysis. Subgroup analyses identified sensitive populations. Restricted cubic spline (RCS) was performed to examine the potential dose-response relationship.
A total of 9464 participants were included in the final analysis. An inverse association between OBS and hyperuricemia was observed and remained after adjusting for potential confounders. Each additional unit of OBS was associated with a 4% and 7% reduction in the risk of hyperuricemia in men [OR: 0.96(0.94,0.99)] and women [OR: 0.93(0.90,0.96)], respectively. Participants in the highest quartile had a 22% and 37% lower risk of hypertension compared with the lowest quartile of OBS in men [0.78(0.62,0.97)] and women [OR: 0.63(0.49,0.79)], respectively. There were significant interactions between OBS and gender, hypertension, and dyslipidemia on hyperuricemia (P < 0.05), except for age, education, and diabetes (P > 0.05). A linear dose-response relationship between OBS and the risk of hyperuricemia (P = 0.7854) was observed.
An inverse association as well as dose-response relationship between OBS and hyperuricemia were observed. Increasing antioxidant levels through lifestyle modification may be an effective way to prevent hyperuricemia, especially in women. Large prospective cohort studies and randomized controlled trials are required to verify the effect of OBS on hyperuricemia and elucidate its causal mechanism.
氧化平衡评分（OBS）是一种综合指标，突出了促氧化剂和抗氧化剂的平衡，代表了氧化应激的总体负担。本研究旨在探讨中国人群中OBS与高尿酸血症之间的关联。
本研究基于2020年8月至2021年4月福建省基于人群的横断面调查数据。OBS根据10种饮食和生活方式的OBS成分确定。使用逻辑回归分析研究OBS与高尿酸血症之间的关联。亚组分析确定了敏感人群。进行受限立方样条（RCS）分析以检查潜在的剂量反应关系。
最终分析共纳入9464名参与者。观察到OBS与高尿酸血症之间存在负相关，在调整潜在混杂因素后仍然存在。OBS每增加一个单位，男性[比值比（OR）：0.96（0.94，0.99）]和女性[OR：0.93（0.90，0.96）]患高尿酸血症的风险分别降低4%和7%。与OBS最低四分位数的参与者相比，最高四分位数的男性[0.78（0.62，0.97）]和女性[OR：0.63（0.49，0.79）]患高尿酸血症的风险分别降低22%和37%。除年龄、教育程度和糖尿病外（P>0.05），OBS与性别、高血压和血脂异常在高尿酸血症方面存在显著交互作用（P<0.05）。观察到OBS与高尿酸血症风险之间存在线性剂量反应关系（P=0.7854）。
观察到OBS与高尿酸血症之间存在负相关以及剂量反应关系。通过生活方式改变提高抗氧化剂水平可能是预防高尿酸血症的有效方法，尤其是在女性中。需要大型前瞻性队列研究和随机对照试验来验证OBS对高尿酸血症的影响并阐明其因果机制。
