Abtan Jeremie, Ducrocq Gregory, Elbez Yedid, Ferrari Roberto, Ford Ian, Fox Kim M, Tardif Jean-Claude, Tendera Michal, Danchin Nicolas, Parkhomenko Alexander, Reid Christopher M, Gabriel Steg P
Université de Paris, Hôpital Bichat, AP-HP, 75018 Paris, France; FACT (French Alliance for Cardiovascular Trials), Paris, France; INSERM U-1148, 75018 Paris, France.
Université de Paris, Hôpital Bichat, AP-HP, 75018 Paris, France.
Arch Cardiovasc Dis. 2023 Aug-Sep;116(8-9):382-389. doi: 10.1016/j.acvd.2023.05.007. Epub 2023 Jul 17.
Conflicting data exist on the association between consumption of coffee or tea and cardiovascular outcomes, and few focus on patients with established coronary artery disease.
To describe the association between coffee or tea consumption and cardiovascular outcomes in patients with stable coronary artery disease, using an extensive contemporary international registry, allowing the identification of multiple potential confounders.
The Prospective Observational Longitudinal Registry of Patients With Stable Coronary Artery Disease (CLARIFY) registry enrolled in 2009 and 2010 in 45 countries, with a 5-year follow-up. Patients were categorized according to daily consumption of coffee or tea, and were compared with those declaring neither. The primary composite outcome of myocardial infarction, stroke or cardiovascular death was analysed at 5years, as well as all-cause mortality. Sensitivity analyses were performed with a multivariable model.
A total of 15,459 and 10,029 patients declared coffee or tea consumption, respectively. At 5years, after full adjustment, no association was found between coffee consumption and the primary outcome: hazard ratio 1.04 (95% confidence interval 0.89-1.21) for 1 cup; 0.94 (0.82-1.08) for 2-3 cups; and 1.04 (0.86-1.27) for ≥4 cups (P=0.51). Drinking tea was not associated with a different incidence of the primary outcome before or after adjustment, with fully adjusted hazard ratios of 1.08 (95% confidence interval 0.84-1.38) for 1 cup, 1.12 (0.96-1.31) for 2-3 cups and 0.95 (0.79-1.14) for ≥4 cups (P=0.30). After full adjustment, neither coffee nor tea drinking was associated with all-cause mortality.
In outpatients with stable coronary artery disease, there was no association between coffee or tea consumption and ischaemic outcomes or all-cause mortality.
关于咖啡或茶的摄入量与心血管疾病结局之间的关联，存在相互矛盾的数据，且很少有研究关注已确诊冠状动脉疾病的患者。
利用一个广泛的当代国际注册研究，确定多种潜在混杂因素，描述稳定型冠状动脉疾病患者咖啡或茶的摄入量与心血管疾病结局之间的关联。
稳定型冠状动脉疾病前瞻性观察纵向注册研究（CLARIFY）于2009年和2010年在45个国家开展，进行了为期5年的随访。患者根据每日咖啡或茶的摄入量进行分类，并与既不喝咖啡也不喝茶的患者进行比较。对心肌梗死、中风或心血管死亡的主要复合结局在5年时进行分析，同时分析全因死亡率。采用多变量模型进行敏感性分析。
分别有15459例和10029例患者报告了咖啡或茶的摄入量。在5年时，经过充分调整后，未发现咖啡摄入量与主要结局之间存在关联：1杯咖啡的风险比为1.04（95%置信区间0.89 - 1.21）；2 - 3杯咖啡的风险比为0.94（0.82 - 1.08）；≥4杯咖啡的风险比为1.04（0.86 - 1.27）（P = 0.51）。在调整前后，饮茶与主要结局的发生率均无差异，1杯茶的完全调整后风险比为1.08（95%置信区间0.84 - 1.38），2 - 3杯茶的风险比为1.12（0.96 - 1.31），≥4杯茶的风险比为0.95（0.79 - 1.14）（P = 0.30）。经过充分调整后，喝咖啡或喝茶均与全因死亡率无关。
在稳定型冠状动脉疾病门诊患者中，咖啡或茶的摄入量与缺血性结局或全因死亡率之间无关联。
