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前沿扫描:英国牛结核病防控的下一步举措是什么?

Horizon scanning: what next for bovine TB control in England?

作者信息

McCormack James

机构信息

Animal and Plant Health Agency, London, UK.

出版信息

Ir Vet J. 2023 Jul 31;76(Suppl 1):18. doi: 10.1186/s13620-023-00242-z.

Abstract

England is currently in year nine of its 25-year strategy to achieve TB freedom. This talk will speculate on what new tools and approaches could be introduced in the future to help us achieve our goal.Using Defra's response to the independent review of its TB programme as a starting point and building on the plenary talk by the UK CVO, I will look at some opportunities that could arise under the different aspects of the response.Firstly, how best to help farmers reduce their herd TB risk through better informed purchasing decisions will be considered, including looking at the recent publication of the health ratings for every cattle herd in England.Cattle vaccination, and its associated DIVA test could be the biggest change in Tb control in England in many years while the related development of a molecularly defined tuberculin which could become the default testing reagent.Advances in whole genome sequencing will allow us to sequence the genome of M.bovis isolated from most infected herds in England and these data could unlock a variety of opportunities from tracing the spread of infection to ground-truthing the efficacy of testing and epidemiological assessment of breakdowns.Finally, the move to vaccination as the primary way of controlling TB in badgers with culling used very sparingly will be considered using a case study of how a targeted badger cull successfully removed infection from an area in Cumbria and enabled the switch to vaccination.

摘要

英国目前正处于其25年结核病消除战略的第九年。本次演讲将推测未来可能引入哪些新工具和方法来帮助我们实现目标。以环境、食品和农村事务部对其结核病计划独立审查的回应为起点,并基于英国首席兽医官的全会演讲,我将探讨在回应的不同方面可能出现的一些机会。首先,将考虑如何通过更明智的采购决策来最好地帮助农民降低其畜群感染结核病的风险,包括查看最近公布的英格兰每头牛群的健康评级。牛疫苗接种及其相关的鉴别诊断测试可能是多年来英国结核病控制方面最大的变化,同时一种分子定义的结核菌素的相关研发可能会成为默认的检测试剂。全基因组测序的进展将使我们能够对从英格兰大多数感染牛群中分离出的牛分枝杆菌基因组进行测序,这些数据可以带来各种机会,从追踪感染传播到验证检测的有效性以及对疫情进行流行病学评估。最后,将以一个案例研究来探讨逐步转向以疫苗接种作为控制獾结核病的主要方式,同时极少使用捕杀手段,该案例研究讲述了有针对性的獾捕杀如何成功地从坎布里亚郡的一个地区消除感染,并得以转向疫苗接种。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6be2/10391754/7fbc49513f09/13620_2023_242_Fig1_HTML.jpg

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