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髋部骨折患者额外周末康复与住院期间死亡率的关系。

Association between additional weekend rehabilitation and in-hospital mortality in patients with hip fractures.

机构信息

Department of Orthopaedic Surgery, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan.

Department of Rehabilitation, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan.

出版信息

Bone Joint J. 2023 Aug 1;105-B(8):872-879. doi: 10.1302/0301-620X.105B8.BJJ-2022-0890.R3.

Abstract

AIMS

The aim of this study was to investigate the association between additional rehabilitation at the weekend, and in-hospital mortality and complications in patients with hip fracture who underwent surgery.

METHODS

A retrospective cohort study was conducted in Japan using a nationwide multicentre database from April 2010 to March 2018, including 572,181 patients who had received hip fracture surgery. Propensity score matching was performed to compare patients who received additional weekend rehabilitation at the weekend in addition to rehabilitation on weekdays after the surgery (plus-weekends group), as well as those who did not receive additional rehabilitation at the weekend but did receive weekday rehabilitation (weekdays-only group). After the propensity score matching of 259,168 cases, in-hospital mortality as the primary outcome and systemic and surgical complications as the secondary outcomes were compared between the two groups.

RESULTS

The plus-weekends group was significantly associated with lower in-hospital mortality rates compared with the weekdays-only group (hazard ratio 0.86; 95% confidence interval 0.8 to 0.92; p < 0.001). Systemic complications such as acute coronary syndrome, heart failure, renal failure, and sepsis were significantly lower in the plus-weekends group, whereas urinary tract infection (UTI) and surgical complications such as surgical site infection and haematoma were significantly higher in the plus-weekends group.

CONCLUSION

Additional weekend rehabilitation was significantly associated with lower in-hospital mortality, as well as acute coronary syndrome, heart failure, renal failure, and sepsis, but was also significantly associated with a higher risk of UTI and surgical complications. This result can facilitate the effective use of the limited rehabilitation resources at the weekend and improve the clinical awareness of specific complications. To establish more robust causal associations between additional rehabilitation over the weekend and clinical outcomes, further prospective studies or randomized controlled trials with larger sample sizes are warranted.

摘要

目的

本研究旨在探讨髋部骨折患者术后周末额外康复治疗与院内死亡率和并发症的关系。

方法

本研究使用日本全国多中心数据库进行回顾性队列研究,纳入 2010 年 4 月至 2018 年 3 月期间接受髋部骨折手术的 572181 例患者。采用倾向评分匹配法比较了在周末除了术后平日康复治疗之外还接受额外周末康复治疗的患者(周末加康复组),以及周末没有接受额外康复治疗但平日接受康复治疗的患者(仅平日康复组)。在进行 259168 例病例的倾向评分匹配后,比较了两组患者的主要结局(院内死亡率)和次要结局(全身和手术并发症)。

结果

与仅平日康复组相比,周末加康复组的院内死亡率显著降低(风险比 0.86;95%置信区间 0.8 至 0.92;p < 0.001)。周末加康复组全身并发症如急性冠状动脉综合征、心力衰竭、肾衰竭和败血症的发生率显著降低,而尿路感染(UTI)和手术并发症如手术部位感染和血肿的发生率显著升高。

结论

周末额外康复治疗与较低的院内死亡率以及急性冠状动脉综合征、心力衰竭、肾衰竭和败血症相关,但也与 UTI 和手术并发症的风险增加相关。该结果有助于有效利用周末有限的康复资源,并提高对特定并发症的临床认识。为了在周末额外康复治疗与临床结局之间建立更稳健的因果关系,需要进一步开展前瞻性研究或更大样本量的随机对照试验。

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