Schlumberger Martin
Association pour la promotion de la médecine préventive (APMP), 01 BP 112, Bobo-Dioulasso, Burkina Faso.
Voir l'éditorial de Pierre SALIOU Place du vaccin polio inactivé dans le Programme élargi de vaccination. Med Trop Sante Int. 2023(3):2:mtsi.v3i2.2023.380.
Med Trop Sante Int. 2023 Jun 2;3(2). doi: 10.48327/mtsi.v3i2.2023.344. eCollection 2023 Jun 30.
In 1980, partners initiated a mobile simplified EPI (Expanded programme on immunization) strategy for immunizing, with mobile teams, rural and urban populations in Western Africa. This strategy delivered EPI vaccines in two sessions: 1) 3-8 month-old children: BCG-Diphteria Tetanus Pertussis + reinforced killed Polio vaccine; 2) 9-15 month-old children: Diphteria Tetanus Pertussis + reinforced killed Polio vaccine, Measles-Yellow Fever. This strategy was compared to WHO-UNICEF extended EPI strategy, but results were never published in the context of a planned rapid polio eradication with oral polio vaccine.
For comparison with standard WHO-UNICEF extended EPI strategy, using oral polio vaccine in four sessions, all the costs generated by these two strategies in 1988 have been collected in two adjacent zones in Burkina Faso, Western Africa: 203,642 inhabitants for WHO-UNICEF extended EPI strategy (Yako); 109,483 inhabitants for mobile simplified EPI strategy (Gourci). An EPI coverage survey at the end of this year has been done in these two adjacent zones with efficiency (costs per fully immunized child) computed.
In Africa, the simplified mobile EPI strategy using reinforced killed polio vaccine was found two times more efficient (12.71 US$ per fully immunized child) than WHO-UNICEF extended EPI strategy using oral polio vaccine (29.67 US$ per fully immunized child), even if DTP-reinforced killed polio vaccine (0.52 US$ per dose) was more expensive than DTP and oral polio vaccine (0.14 US$ for the combined dose). The missed opportunities uncaught up would have doubled coverage in the WHO-UNICEF extended EPI strategy, versus only a 10% increase with the mobile simplified EPI strategy. The main reason for uncaught up missed opportunities in WHO extended EPI strategy was the absence of requested vaccine delivered by a health agent when attending population at meeting point, due to insufficient cold box volume carried on his moped for transport of vaccine.
After 30 years, since 1990, of poliomyelitis eradication in Africa using oral polio vaccine and with non-added costs in this study of polio mass campaigns, these results should be published to review EPI strategy.
1980年,合作伙伴发起了一项流动简化扩大免疫规划(EPI)战略,通过流动团队为西非城乡人口进行免疫接种。该战略分两次接种EPI疫苗:1)3至8个月大的儿童:卡介苗-白喉-破伤风-百日咳+强化灭活脊髓灰质炎疫苗;2)9至15个月大的儿童:白喉-破伤风-百日咳+强化灭活脊髓灰质炎疫苗、麻疹-黄热病。该战略与世界卫生组织-联合国儿童基金会的扩大EPI战略进行了比较,但在计划使用口服脊髓灰质炎疫苗快速根除脊髓灰质炎的背景下,结果从未发表。
为了与世界卫生组织-联合国儿童基金会的标准扩大EPI战略(分四次使用口服脊髓灰质炎疫苗)进行比较,1988年这两种战略产生的所有成本已在西非布基纳法索的两个相邻地区收集:世界卫生组织-联合国儿童基金会扩大EPI战略(亚科)覆盖203,642名居民;流动简化EPI战略(古尔西)覆盖109,483名居民。年底在这两个相邻地区进行了EPI覆盖率调查,并计算了效率(每个完全免疫儿童的成本)。
在非洲,使用强化灭活脊髓灰质炎疫苗的简化流动EPI战略被发现效率比使用口服脊髓灰质炎疫苗的世界卫生组织-联合国儿童基金会扩大EPI战略高出两倍(每个完全免疫儿童1美元),即使白喉-破伤风-百日咳-强化灭活脊髓灰质炎疫苗(每剂0.52美元)比白喉-破伤风-百日咳和口服脊髓灰质炎疫苗(联合剂量0.14美元)更贵。未弥补的错失机会在世界卫生组织-联合国儿童基金会扩大EPI战略中会使覆盖率翻倍,而在流动简化EPI战略中只会增加10%。世界卫生组织扩大EPI战略中未弥补错失机会的主要原因是,卫生人员在集合点为人群服务时,由于其助力车上携带的冷藏箱体积不足以运输疫苗,导致所需疫苗未送达。
自1990年以来,在非洲使用口服脊髓灰质炎疫苗根除脊髓灰质炎已有30年,且本研究中脊髓灰质炎大规模疫苗接种运动没有额外成本,这些结果应予以发表以审查EPI战略。