Department of Cell Biology and Physiology and the Neuroscience Center, College of Life Sciences, Brigham Young University, Provo, UT 84602, USA.
Front Biosci (Landmark Ed). 2023 Jul 27;28(7):154. doi: 10.31083/j.fbl2807154.
While cannabidiol (CBD) and 4',7-isoflavandiol (Equol) have been examined individually in various skin studies, the present investigation tested whether topically applied CBD with Equol may yield enhanced effects on human skin biomarkers.
After 24 hours exposure human skin gene expression was measured by quantitative polymerase chain reaction-messenger ribonucleic acid (qPCR-mRNA) analysis across 9 functional skin categories covering 97 biomarkers.
In general, among the biomarkers analyzed the CBD with Equol treatment displayed greater efficacy compared to CBD only or the Equol treatment alone (e.g., 4 out 5 for anti-acne, 15 out of 17 for anti-aging [e.g., collagen, elastin, calcium binding protein A7, tissue inhibitor of matrix metalloproteinase 1 (), etc.], 19 out of 21 for anti-inflammatory (pain), 10 out of 11 for antioxidants to protect against oxidative stress, 6 out of 6 for circadian rhythm regulation for cell repair/restoration, 10 out of 15 for anti-pigmentation properties, 4 out of 5 for skin hydration, 6 out of 6 for tissue integrity, and 11 out of 12 for wound healing properties).
CBD with Equol displayed synergistic effects that may be an effective topical treatment for dermatology and cosmetic applications to improve human skin health and reduce photo-aging.
虽然大麻二酚（CBD）和 4',7-异黄烷二醇（Equol）已在各种皮肤研究中进行了单独研究，但本研究测试了局部应用 CBD 与 Equol 是否可能对人体皮肤生物标志物产生增强作用。
在 24 小时暴露后，通过定量聚合酶链反应-信使核糖核酸（qPCR-mRNA）分析，对涵盖 97 个生物标志物的 9 个功能皮肤类别中的人类皮肤基因表达进行了测量。
一般来说，在所分析的生物标志物中，CBD 与 Equol 治疗的效果优于 CBD 单独或 Equol 单独治疗（例如，抗粉刺有 4 种，抗老化有 15 种[例如，胶原蛋白、弹性蛋白、钙结合蛋白 A7、基质金属蛋白酶 1 组织抑制剂（）等]、抗炎（疼痛）有 19 种、抗氧化剂有 10 种以防止氧化应激、生物钟节律调节有 6 种以促进细胞修复/恢复、抗色素沉着有 10 种、皮肤保湿有 4 种、组织完整性有 6 种、伤口愈合有 11 种）。
CBD 与 Equol 显示出协同作用，可能是皮肤科和化妆品应用的有效局部治疗方法，可改善人体皮肤健康并减少光老化。
