Mejía-Aranguré Juan Manuel, Núñez-Enríquez Juan Carlos
Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Cancer Epidemiol Biomarkers Prev. 2023 Aug 1;32(8):999-1002. doi: 10.1158/1055-9965.EPI-23-0587.
The frequency of acute lymphoblastic leukemia (ALL) has been reported with a higher incidence among the populations of Hispanic children. However, in the article by Montes-Rodríguez and colleagues, they found that in the Puerto Rican population, the frequency was below the incidence reported for the U.S. Hispanic pediatric population, but they found that the incidence of ALL had an annual increase of 5%. In other Hispanic pediatric populations during the 1980s, the incidence of ALL was found to be even lower than the general rate in the United States. However, in less than 20 years that incidence had already been exceeded. It is evident that the Hispanic pediatric population is more susceptible to develop ALL than other populations, so it is important to consider that what is happening to the pediatric population of Puerto Rico gives us a great opportunity to identify risk factors that could potentially explain this increase. It is more likely that the risk factors that are capable of causing ALL could be identified in their role in the origin of the disease in populations with high susceptibility, given the greater number of cases of ALL that said factor is causing in that population. See related article by Montes-Rodríguez et al., p. 1030.
据报道，急性淋巴细胞白血病（ALL）在西班牙裔儿童人群中的发病率较高。然而，在蒙特斯 - 罗德里格斯及其同事的文章中，他们发现，在波多黎各人群中，该发病率低于美国西班牙裔儿科人群的报告发病率，但他们发现ALL的发病率每年增长5%。在20世纪80年代的其他西班牙裔儿科人群中，ALL的发病率甚至低于美国的总体发病率。然而，在不到20年的时间里，这一发病率就已被超过。显然，西班牙裔儿科人群比其他人群更容易患ALL，因此，重要的是要认识到，波多黎各儿科人群中发生的情况为我们提供了一个绝佳机会，来识别可能解释这种增长的风险因素。鉴于该因素在高易感性人群中导致的ALL病例数量更多，在高易感性人群中更有可能识别出能够引发ALL的风险因素在疾病起源中的作用。见蒙特斯 - 罗德里格斯等人的相关文章，第1030页。
