Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia.
Department of Neurology, University of Pecs, Pecs, Hungary.
J Neural Transm (Vienna). 2023 Nov;130(11):1405-1409. doi: 10.1007/s00702-023-02680-z. Epub 2023 Aug 1.
In the advanced Parkinson's disease, motor and non-motor symptoms become more severe and more difficult to treat. Oral therapy may become insufficient in controlling a patient´s motor complications, which results in a substantial deterioration of the patient's quality of life, ability to work and self-reliance. This is when device-aided treatments should be considered and offered, if suitable for a given patient. They include subcutaneous and intestinal infusion therapies, deep brain stimulation and, more recently, MRI-guided focussed ultrasound. Device-aided treatments should be offered in accordance with guidelines and treatment standardization. Also there is a need to ensure availability of treatment and education of patients and physicians.
在晚期帕金森病中，运动和非运动症状变得更加严重且更难以治疗。口服治疗可能不足以控制患者的运动并发症，这会导致患者的生活质量、工作能力和自理能力大幅下降。此时应考虑并提供器械辅助治疗，如果适合特定患者的话。这些治疗包括皮下和肠道输注疗法、深部脑刺激，以及最近出现的 MRI 引导聚焦超声。器械辅助治疗应根据指南和治疗标准化来提供。此外，还需要确保治疗的可及性和对患者及医生的教育。
