Wagner-Mann C C, Gross D R
Am J Vet Res. 1986 Aug;47(8):1763-6.
The efficacy of treating hemorrhagic shock with naloxone in conjunction with fluids, compared with fluid therapy alone, was studied. Previously instrumented dogs were anesthetized with 0.04 mg of fentanyl/kg + 2.2 mg of droperidol/kg and pentobarbital sodium (to effect). Blood was withdrawn from each animal to achieve and maintain a mean arterial blood pressure of 40 to 50 mm of Hg for the first 2 hours of the experiment (t = 0 to 120 minutes). At t = 120 minutes, IV fluid administration was begun (all dogs) and continued for 1 hour (lactated Ringer's solution at a dosage of 70 ml/kg/hr). Hypothermia was corrected. Control dogs were given no other treatment. Dogs in the naloxone plus fluids group were given an IV bolus of naloxone (1 mg/kg) at t = 120 minutes and 1 mg of naloxone/kg/hr in the fluids from t = 120 to t = 180 minutes. Treatment (either naloxone plus fluids or fluids alone) was stopped at t = 180 minutes, and measuring of response was continued for an additional hour (posttherapeutic period). Significant differences were not seen in mean arterial pressures, left ventricular peak systolic pressures, dP/dt max, time constant T (a measure of left ventricular elasticity), and mean pulmonary arterial pressures between the dogs given naloxone and fluid therapy and those given fluid therapy alone. All dogs in both groups survived the procedure.
研究了纳洛酮联合液体治疗失血性休克的疗效，并与单纯液体疗法进行比较。预先植入仪器的犬只用0.04mg/kg芬太尼 + 2.2mg/kg氟哌利多和戊巴比妥钠麻醉（至起效）。在实验的前2小时（t = 0至120分钟），从每只动物身上抽血，使平均动脉血压达到并维持在40至50mmHg。在t = 120分钟时，开始静脉输注液体（所有犬只）并持续1小时（乳酸林格氏液，剂量为70ml/kg/hr）。纠正体温过低。对照犬只未接受其他治疗。纳洛酮加液体组的犬只在t = 120分钟时静脉推注纳洛酮（1mg/kg），并在t = 120至t = 180分钟期间在液体中加入1mg/kg/hr纳洛酮。在t = 180分钟时停止治疗（纳洛酮加液体或单纯液体），并在额外的1小时内继续测量反应（治疗后阶段）。接受纳洛酮和液体治疗的犬只与单纯接受液体治疗的犬只在平均动脉压、左心室收缩压峰值、dP/dt max、时间常数T（左心室弹性的一种测量）和平均肺动脉压方面未见显著差异。两组中的所有犬只均在该过程中存活。
