Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China.
Department of Pediatric and Preventive Dentistry, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China.
Drug Deliv Transl Res. 2024 Jan;14(1):247-265. doi: 10.1007/s13346-023-01397-6. Epub 2023 Aug 1.
Oral leukoplakia (OLK) has received much attention due to its potential risk of malignant transformation. Studies have shown that when drug therapy is combined with photothermal therapy (PTT), not only can the cytotoxicity of the drug be enhanced, but also the heat energy can be used to kill the lesion cells, so we can combine drug therapy with PTT to enhance the therapeutic effect on OLK. However, with certain drawbacks due to its lack of targeting, fibroblast activating protein (FAP) has become an attractive target for OLK combination therapy. In this study, we used NGO-PEG loaded with FAP-targeting peptide (F-TP) and celecoxib (CXB) to construct a nano-drug delivery system CGPF for targeting OLK with high FAP expression and confirmed the biocompatibility and therapeutic efficacy of CGPF by in vitro and in vivo experiments. Overall, the novel nano-drug delivery system CGPF proposed in this study showed a very significant potential for the combination therapy of OLK.
口腔白斑病（OLK）因其潜在的恶变风险而备受关注。研究表明，药物治疗联合光热治疗（PTT）不仅可以增强药物的细胞毒性，还可以利用热能杀死病变细胞，因此我们可以将药物治疗与 PTT 相结合，以增强对 OLE 的治疗效果。然而，由于其缺乏靶向性，成纤维细胞激活蛋白（FAP）已成为 OLK 联合治疗的一个有吸引力的靶点。在这项研究中，我们使用 NGO-PEG 负载 FAP 靶向肽（F-TP）和塞来昔布（CXB）构建了一种纳米药物递送系统 CGPF，用于靶向高 FAP 表达的 OLK，并通过体外和体内实验证实了 CGPF 的生物相容性和治疗效果。总的来说，本研究提出的新型纳米药物递送系统 CGPF 对 OLK 的联合治疗具有非常显著的潜力。
