Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, Nanjing, 210008, China.
Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, No 30 Zhongyang Road, Nanjing, 210008, China.
J Nanobiotechnology. 2022 Mar 4;20(1):106. doi: 10.1186/s12951-022-01310-2.
Oral leukoplakia (OLK) has gained extensive attention because of the potential risk for malignant transformation. Photosensitizers (PSs) played an indispensable role in the photodynamic therapy (PDT) of OLK, but the poor light sensitivity greatly hampered its clinical application. Herein, a novel organic photosensitive ITIC-Th nanoparticles (ITIC-Th NPs) were developed for OLK photodynamic/photothermal therapy (PTT). ITIC-Th NPs present both high photothermal conversion efficiency (~ 38%) and suitable reactive oxygen species (ROS) generation ability under 660 nm laser irradiation, making them possess excellent PDT and PTT capability. In 4-nitroquinoline 1-oxide (4NQO)-induced oral precancerous animal models, ITIC-Th NPs effectively suppress the OLK's cancerization without apparent topical or systemic toxicity in vivo. This study offers a promising therapeutic strategy for PDT and PTT in OLK treatment, and this study is the first interdisciplinary research in the field of multimodal therapy for OLK.
口腔白斑病（OLK）由于恶性转化的潜在风险而受到广泛关注。光增敏剂（PSs）在 OLK 的光动力疗法（PDT）中起着不可或缺的作用，但较差的光敏感性极大地阻碍了其临床应用。在此，开发了一种新型有机光敏 ITIC-Th 纳米粒子（ITIC-Th NPs）用于 OLK 光动力/光热治疗（PTT）。在 660nm 激光照射下，ITIC-Th NPs 具有高光热转换效率（~38%）和合适的活性氧（ROS）生成能力，使其具有优异的 PDT 和 PTT 能力。在 4-硝基喹啉 1-氧化物（4NQO）诱导的口腔癌前动物模型中，ITIC-Th NPs 有效地抑制了 OLK 的癌变，同时在体内无明显的局部或全身毒性。本研究为 OLK 治疗中的 PDT 和 PTT 提供了一种有前途的治疗策略，这是 OLK 多模态治疗领域的首次跨学科研究。
