Novel Long Noncoding RNAs, and , Serve as Potential Diagnostic and Prognostic Biomarkers or Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is one of the most fatal human malignancies worldwide. In this research, we aimed to identify long noncoding RNAs (lncRNAs) as biomarkers for HCC diagnosis and prognosis. lncRNA expression profiles were obtained from Gene Expression Omnibus and The Cancer Genome Atlas databases. The differentially expressed lncRNAs between HCC and adjacent tissues were analyzed with bioinformatic tools. Four lncRNAs with area under the curve of the receiver operating characteristic curve >0.9 were selected from both datasets. Univariate and Kaplan-Meier analyses were performed to obtain , , and as the optimal diagnostic and prognostic biomarkers. Finally, qPCR confirmed that and were significantly differentially expressed in HCC and adjacent normal tissues. In general, we demonstrated that novel lncRNAs, and , could be used as potential diagnostic and prognostic biomarkers for HCC.