Stempien A, Katz A M, Messineo F C
Ann Intern Med. 1986 Oct;105(4):603-6. doi: 10.7326/0003-4819-105-4-603.
Calcium has a central role in regulating both cardiac automaticity and myocardial contractility. The ability of calcium to increase tension in normal myocardium is well known. These properties of calcium have led to its use in the setting of cardiopulmonary resuscitation, especially in the presence of electromechanical dissociation or asystole, but evidence of benefit from this therapy is lacking. During cardiac arrest, disturbances in the control of calcium movement in myocardium would likely result in elevations in cytosolic calcium and the disturbances in myocardial function that occur with calcium overload. Administration of calcium and the subsequent elevation in serum calcium concentrations under these conditions may have further detrimental effects on the heart and vascular smooth muscle. The routine use of calcium in cardiac arrest is not recommended.
钙在调节心脏自律性和心肌收缩性方面起着核心作用。钙能增加正常心肌张力的能力是众所周知的。钙的这些特性使其被用于心肺复苏，尤其是在存在电机械分离或心搏停止的情况下，但缺乏这种治疗有益的证据。在心脏骤停期间，心肌中钙转运控制的紊乱可能会导致胞浆钙升高以及钙超载时出现的心肌功能紊乱。在这些情况下给予钙以及随后血清钙浓度的升高可能会对心脏和血管平滑肌产生进一步的有害影响。不建议在心脏骤停时常规使用钙。
