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随机临床试验研究了针对幼儿母亲的戒烟经济激励措施,以及这些措施对儿童二手烟暴露的可能影响。

Randomized clinical trial examining financial incentives for smoking cessation among mothers of young children and possible impacts on child secondhand smoke exposure.

机构信息

Vermont Center on Behavior and Health, University of Vermont, United States of America; Department of Psychiatry, University of Vermont, United States of America; Department of Psychological Science, University of Vermont, United States of America.

Vermont Center on Behavior and Health, University of Vermont, United States of America; Department of Psychiatry, University of Vermont, United States of America.

出版信息

Prev Med. 2023 Nov;176:107651. doi: 10.1016/j.ypmed.2023.107651. Epub 2023 Jul 30.

Abstract

This randomized clinical trial examined whether financial-incentives increase smoking cessation among mothers of young children and potential impacts on child secondhand-smoke exposure (SHSe). 198 women-child dyads were enrolled and assigned to one of three treatment conditions: best practices (BP, N = 68), best practices plus financial incentives (BP + FI, N = 63), or best practices, financial incentives, and nicotine replacement therapy (BP + FI + NRT, N = 67). The trial was completed in Vermont, USA between June 2015 and October 2020. BP entailed staff referral to the state tobacco quitline; financial incentives entailed mothers earning vouchers exchangeable for retail items for 12 weeks contingent on biochemically-verified smoking abstinence; NRT involved mothers receiving 10 weeks of free transdermal nicotine and nicotine lozenges/gum. Baseline, 6-, 12-, 24-, and 48-week assessments were conducted. Primary outcomes were maternal 7-day point-prevalence abstinence and child SHSe through the 24-week assessment with the 48-week assessment exploratory. Results were analyzed using mixed model repeated measures for categorical data. Odds of maternal abstinence were greater among mothers in BP + FI and BP + FI + NRT compared to BP at the 6- and 12-week assessments (ORs ≥ 7.30; 95% CIs: 2.35-22.71); only abstinence in BP + FI remained greater than BP at the 24-week assessment (OR = 2.95; 95% CIs: 1.06-8.25). Abstinence did not differ significantly between treatment conditions at the 48-week assesssment. There was a significant effect of treatment condition (F[2109] = 3.64, P = .029) on SHSe with levels in BP and BP + FI significantly below BP + FI + NRT (ts[109] ≥ -2.30, Ps ≤ 0.023). Financial incentives for smoking abstinence are efficacious for increasing maternal cessation but that alone was insufficient for reducing child SHSe. ClinicalTrials.gov:NCT05740098.

摘要

这项随机临床试验旨在研究经济激励措施是否能提高幼儿母亲的戒烟率,以及对儿童二手烟暴露(SHSe)的潜在影响。198 对母婴二人组被纳入并分配到以下三种治疗条件之一:最佳实践(BP,N=68)、最佳实践加经济激励(BP+FI,N=63)或最佳实践、经济激励和尼古丁替代疗法(BP+FI+NRT,N=67)。该试验于 2015 年 6 月至 2020 年 10 月在美国佛蒙特州完成。BP 包括工作人员向州烟草戒烟热线推荐;经济激励措施要求母亲在生物化学验证的戒烟后 12 周内获得可兑换零售商品的代金券;NRT 涉及母亲接受 10 周的免费透皮尼古丁和尼古丁含片/口香糖。在基线、6 周、12 周、24 周和 48 周进行评估。主要结局是母亲的 7 天点预期限期戒烟率和儿童在 24 周评估时的 SHSe,48 周评估为探索性评估。使用混合模型重复测量对分类数据进行分析。与 BP 相比,BP+FI 和 BP+FI+NRT 组的母亲在 6 周和 12 周评估时更有可能实现完全戒烟(OR≥7.30;95%CI:2.35-22.71);只有 BP+FI 组的戒烟率在 24 周评估时仍高于 BP 组(OR=2.95;95%CI:1.06-8.25)。在 48 周评估时,不同治疗条件之间的戒烟率没有显著差异。治疗条件(F[2109]=3.64,P=0.029)对 SHSe 有显著影响,BP 和 BP+FI 组的水平明显低于 BP+FI+NRT 组(ts[109]≥-2.30,Ps≤0.023)。经济激励措施对于提高母亲的戒烟率是有效的,但单独使用不足以降低儿童的 SHSe。ClinicalTrials.gov:NCT05740098。

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Cochrane Database Syst Rev. 2020 Mar 4;3(3):CD010078. doi: 10.1002/14651858.CD010078.pub3.

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