Amedro Pascal, Matecki Stefan, Pereira Dos Santos Taissa, Guillaumont Sophie, Rhodes Jonathan, Yin Suellen Moli, Hager Alfred, Hock Julia, De La Villeon Gregoire, Moreau Johan, Requirand Anne, Souilla Luc, Vincenti Marie, Picot Marie-Christine, Huguet Helena, Mura Thibault, Gavotto Arthur
Department of Paediatric and Congenital Cardiology, M3C National Reference Centre, Bordeaux University Hospital, 1 Avenue Magellan, 33604, Pessac, France.
IHU Liryc, Electrophysiology and Heart Modelling Institute, INSERM 1045, Bordeaux University Foundation, Avenue du Haut Lévêque, 33600, Pessac, France.
Sports Med Open. 2023 Aug 1;9(1):68. doi: 10.1186/s40798-023-00622-3.
The evaluation of health status by cardiopulmonary exercise test (CPET) has shown increasing interest in the paediatric population. Our group recently established reference Z-score values for paediatric cycle ergometer VO, applicable to normal and extreme weights, from a cohort of 1141 healthy children. There are currently no validated reference values for the other CPET parameters in the paediatric population. This study aimed to establish, from the same cohort, reference Z-score values for the main paediatric cycle ergometer CPET parameters, apart from VO.
In this cross-sectional study, 909 healthy children aged 5-18 years old underwent a CPET. Linear, quadratic, and polynomial mathematical regression equations were applied to identify the best CPET parameters Z-scores, according to anthropometric parameters (sex, age, height, weight, and BMI). This study provided Z-scores for maximal CPET parameters (heart rate, respiratory exchange ratio, workload, and oxygen pulse), submaximal CPET parameters (ventilatory anaerobic threshold, VE/VCO slope, and oxygen uptake efficiency slope), and maximum ventilatory CPET parameters (tidal volume, respiratory rate, breathing reserve, and ventilatory equivalent for CO and O).
This study defined paediatric reference Z-score values for the main cycle ergometer CPET parameters, in addition to the existing reference values for VO, applicable to children of normal and extreme weights. Providing Z-scores for CPET parameters in the paediatric population should be useful in the follow-up of children with various chronic diseases. Thus, new paediatric research fields are opening up, such as prognostic studies and clinical trials using cardiopulmonary fitness outcomes. Trial registration NCT04876209-Registered 6 May 2021-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04876209 .
通过心肺运动试验（CPET）评估健康状况在儿科人群中越来越受到关注。我们的团队最近从1141名健康儿童队列中建立了适用于正常体重和极端体重儿童的儿科自行车测力计VO的参考Z评分值。目前儿科人群中其他CPET参数尚无经过验证的参考值。本研究旨在从同一队列中建立除VO外主要儿科自行车测力计CPET参数的参考Z评分值。
在这项横断面研究中，909名5至18岁的健康儿童接受了CPET。根据人体测量参数（性别、年龄、身高、体重和BMI），应用线性、二次和多项式数学回归方程来确定最佳CPET参数Z评分。本研究提供了最大CPET参数（心率、呼吸交换率、工作量和氧脉搏）、次最大CPET参数（通气无氧阈值、VE/VCO斜率和摄氧效率斜率）以及最大通气CPET参数（潮气量、呼吸频率、呼吸储备以及CO和O的通气当量）的Z评分。
本研究除了现有的VO参考值外，还定义了主要自行车测力计CPET参数的儿科参考Z评分值，适用于正常体重和极端体重的儿童。为儿科人群的CPET参数提供Z评分在各种慢性病儿童的随访中应该是有用的。因此，新的儿科研究领域正在开辟，例如使用心肺适能结果的预后研究和临床试验。试验注册NCT04876209 - 2021年5月6日注册 - 回顾性注册，https://clinicaltrials.gov/ct2/show/NCT04876209 。
