肥胖患者因用药剂量不足导致青蒿琥酯-哌喹治疗疟疾发作延迟失败。
Late dihydroartemisinin-piperaquine treatment failure of malaria attack related to insufficient dosing in an obese patient.
作者信息
Parisey M, Houze S, Bailly J, Taudon N, Jaffal K, Argy N, Rouzaud C, Mégarbane B, Lariven S, Yazdanpanah Y, Matheron S
机构信息
Department of Infectious Diseases, Bichat Hospital, AP-HP, Paris, France.
Department of Infectious Diseases, Delafontaine Hospital, Saint Denis, France.
出版信息
IDCases. 2023 Jul 8;33:e01847. doi: 10.1016/j.idcr.2023.e01847. eCollection 2023.
Abstract
We report the case of an obese patient who experienced late failure on day28 of a well-conducted treatment with artesunate, followed by dihydroartemisinin-piperaquine (DHA-PPQ) for a severe malaria attack. The same strain was evidenced at day0 and day28. Genotypic and phenotypic resistance tests could not explain this treatment failure. The low plasma piperaquine concentration at failure may explain the poor elimination of residual parasites.
摘要
我们报告了一例肥胖患者的病例，该患者在接受青蒿琥酯规范治疗第28天时出现晚期治疗失败，随后因严重疟疾发作接受双氢青蒿素哌喹（DHA-PPQ）治疗。在第0天和第28天检测到相同的疟原虫株。基因型和表型耐药性检测无法解释此次治疗失败。治疗失败时血浆哌喹浓度较低可能解释了残余寄生虫清除不佳的原因。
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