塞内加尔实施双氢青蒿素-哌喹之前恶性疟原虫分离株的基线和分子反应对哌喹的反应
Baseline and Molecular Responses of Plasmodium falciparum Isolates to Piperaquine before Implementation of Dihydroartemisinin-Piperaquine in Senegal.
机构信息
Unité Parasitologie et Entomologie, Département de Microbiologie et de Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France.
Aix Marseille University, IRD, SSA, AP-HM, VITROME, Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France.
出版信息
Antimicrob Agents Chemother. 2019 Apr 25;63(5). doi: 10.1128/AAC.02445-18. Print 2019 May.
Abstract
Dihydroartemisinin-piperaquine, which was registered in 2017 in Senegal, is not currently used as the first-line treatment against uncomplicated malaria. A total of 6.6% to 17.1% of isolates collected in Dakar in 2013 to 2015 showed -reduced susceptibility to piperaquine. Neither the exonuclease E415G mutation nor the copy number variation of the gene (), associated with piperaquine resistance in Cambodia, was detected in Senegalese parasites.
摘要
双氢青蒿素-哌喹，于 2017 年在塞内加尔注册，目前不作为治疗无并发症疟疾的一线药物。2013 年至 2015 年在达喀尔采集的分离株中，有 6.6%至 17.1%对哌喹的敏感性降低。在塞内加尔寄生虫中，既没有检测到与柬埔寨哌喹耐药相关的外切酶 E415G 突变，也没有检测到 基因（）的拷贝数变异。
相似文献
1
Baseline and Molecular Responses of Plasmodium falciparum Isolates to Piperaquine before Implementation of Dihydroartemisinin-Piperaquine in Senegal.塞内加尔实施双氢青蒿素-哌喹之前恶性疟原虫分离株的基线和分子反应对哌喹的反应
Antimicrob Agents Chemother. 2019 Apr 25;63(5). doi: 10.1128/AAC.02445-18. Print 2019 May.
2
A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype-genotype association study.耐哌喹恶性疟原虫疟疾的替代标志物：一项表型-基因型关联研究。
Lancet Infect Dis. 2017 Feb;17(2):174-183. doi: 10.1016/S1473-3099(16)30415-7. Epub 2016 Nov 3.
3
Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study.中医疗法治疗失败的决定因素：柬埔寨、泰国和越南间日疟原虫疟疾的前瞻性临床、药理学和遗传学研究。
Lancet Infect Dis. 2019 Sep;19(9):952-961. doi: 10.1016/S1473-3099(19)30391-3. Epub 2019 Jul 22.
4
Genetic markers associated with dihydroartemisinin-piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype-phenotype association study.柬埔寨恶性疟原虫疟疾中与双氢青蒿素-哌喹治疗失败相关的遗传标记：一项基因型-表型关联研究。
Lancet Infect Dis. 2017 Feb;17(2):164-173. doi: 10.1016/S1473-3099(16)30409-1. Epub 2016 Nov 3.
5
Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study.柬埔寨三突变（包括kelch13 C580Y）导致双氢青蒿素-哌喹耐药：一项观察性队列研究。
Lancet Infect Dis. 2015 Jun;15(6):683-91. doi: 10.1016/S1473-3099(15)70049-6. Epub 2015 Apr 12.
6
Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa?在东南亚，k13 和疟原虫裂殖子表面蛋白 2（plasmepsin II）基因与对青蒿素衍生物和哌喹的耐药性有关，那么这些基因是否可用于监测非洲的耐药性？
Malar J. 2019 Aug 23;18(1):285. doi: 10.1186/s12936-019-2916-6.
7
Absence of a High Level of Duplication of the Plasmepsin II Gene in Africa.在非洲不存在高水平的疟原虫Ⅱ型裂殖子蛋白基因重复。
Antimicrob Agents Chemother. 2018 Oct 24;62(11). doi: 10.1128/AAC.00374-18. Print 2018 Nov.
8
Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity.恶性疟原虫氯喹抗性转运蛋白中的一种新型突变与哌喹敏感性降低的关联。
J Infect Dis. 2017 Aug 15;216(4):468-476. doi: 10.1093/infdis/jix334.
9
A single point mutation in the Plasmodium falciparum 3'-5' exonuclease does not alter piperaquine susceptibility.恶性疟原虫3'-5'核酸外切酶中的单点突变不会改变对哌喹的敏感性。
Malar J. 2022 Apr 22;21(1):130. doi: 10.1186/s12936-022-04148-z.
10
Piperaquine resistant Cambodian Plasmodium falciparum clinical isolates: in vitro genotypic and phenotypic characterization.哌喹耐药柬埔寨疟原虫临床分离株的体外基因和表型特征。
Malar J. 2020 Jul 25;19(1):269. doi: 10.1186/s12936-020-03339-w.
引用本文的文献
1
Rapid detection of mutations in the suspected piperaquine resistance gene E415G-exo in Plasmodium falciparum exonuclease via AS‒PCR and RAA with CRISPR/Cas12a.通过AS-PCR和带有CRISPR/Cas12a的RAA快速检测恶性疟原虫核酸外切酶中疑似哌喹抗性基因E415G-exo的突变
Int J Parasitol Drugs Drug Resist. 2024 Dec;26:100568. doi: 10.1016/j.ijpddr.2024.100568. Epub 2024 Oct 28.
2
Late dihydroartemisinin-piperaquine treatment failure of malaria attack related to insufficient dosing in an obese patient.肥胖患者因用药剂量不足导致青蒿琥酯-哌喹治疗疟疾发作延迟失败。
IDCases. 2023 Jul 8;33:e01847. doi: 10.1016/j.idcr.2023.e01847. eCollection 2023.
3
A single point mutation in the Plasmodium falciparum 3'-5' exonuclease does not alter piperaquine susceptibility.恶性疟原虫3'-5'核酸外切酶中的单点突变不会改变对哌喹的敏感性。
Malar J. 2022 Apr 22;21(1):130. doi: 10.1186/s12936-022-04148-z.
4
Absence of Association between Methylene Blue Reduced Susceptibility and Polymorphisms in 12 Genes Involved in Antimalarial Drug Resistance in African .非洲地区亚甲蓝敏感性降低与12个抗疟药物耐药相关基因多态性之间不存在关联。
Pharmaceuticals (Basel). 2021 Apr 9;14(4):351. doi: 10.3390/ph14040351.
5
Piperaquine resistant Cambodian Plasmodium falciparum clinical isolates: in vitro genotypic and phenotypic characterization.哌喹耐药柬埔寨疟原虫临床分离株的体外基因和表型特征。
Malar J. 2020 Jul 25;19(1):269. doi: 10.1186/s12936-020-03339-w.
6
Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates.恶性疟原虫氯喹耐药转运蛋白（PfCRT）基因突变的流行情况及其与非洲恶性疟原虫分离株体外常见抗疟药物敏感性的关系。
Malar J. 2020 Jun 5;19(1):201. doi: 10.1186/s12936-020-03281-x.
7
Low polymorphisms in pfact, pfugt and pfcarl genes in African Plasmodium falciparum isolates and absence of association with susceptibility to common anti-malarial drugs.非洲恶性疟原虫分离株中 pfact、pfugt 和 pfcarl 基因的低多态性与常见抗疟药物敏感性无关。
Malar J. 2019 Aug 28;18(1):293. doi: 10.1186/s12936-019-2919-3.
8
Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa?在东南亚，k13 和疟原虫裂殖子表面蛋白 2（plasmepsin II）基因与对青蒿素衍生物和哌喹的耐药性有关，那么这些基因是否可用于监测非洲的耐药性？
Malar J. 2019 Aug 23;18(1):285. doi: 10.1186/s12936-019-2916-6.
本文引用的文献
1
Efficacy and safety of artemisinin-based combination therapy, and molecular markers for artemisinin and piperaquine resistance in Mainland Tanzania.中国内地青蒿素类复方疗法的疗效和安全性，以及青蒿素和哌喹耐药性的分子标志物。
Malar J. 2018 Oct 17;17(1):369. doi: 10.1186/s12936-018-2524-x.
2
Absence of a High Level of Duplication of the Plasmepsin II Gene in Africa.在非洲不存在高水平的疟原虫Ⅱ型裂殖子蛋白基因重复。
Antimicrob Agents Chemother. 2018 Oct 24;62(11). doi: 10.1128/AAC.00374-18. Print 2018 Nov.
3
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine.出现的东南亚 PfCRT 突变使恶性疟原虫对一线抗疟药哌喹产生耐药性。
Nat Commun. 2018 Aug 17;9(1):3314. doi: 10.1038/s41467-018-05652-0.
4
Dihydroartemisinin-piperaquine treatment failure in uncomplicated Plasmodium falciparum malaria case imported from Ethiopia.从埃塞俄比亚输入的无并发症恶性疟原虫疟疾患者采用二氢青蒿素-哌喹治疗失败。
Infection. 2018 Dec;46(6):867-870. doi: 10.1007/s15010-018-1174-9. Epub 2018 Jul 6.
5
Efficacy of artemisinin-based combination therapies and prevalence of molecular markers associated with artemisinin, piperaquine and sulfadoxine-pyrimethamine resistance in Sierra Leone.基于青蒿素的联合疗法的疗效以及与青蒿素、哌喹和磺胺多辛-乙胺嘧啶耐药性相关的分子标志物在塞拉利昂的流行情况。
Acta Trop. 2018 Sep;185:363-370. doi: 10.1016/j.actatropica.2018.06.016. Epub 2018 Jun 19.
6
Plasmodium falciparum Plasmepsin 2 Duplications, West Africa.恶性疟原虫（Plasmodium falciparum）Plasmepsin 2 基因重复，西非。
Emerg Infect Dis. 2018 Aug;24(8):1591-3. doi: 10.3201/eid2408.180370. Epub 2018 Aug 17.
7
Plasmepsin II-III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum.裂殖体朊酶 II-III 拷贝数解释柬埔寨疟原虫哌喹双模态耐药性。
Nat Commun. 2018 May 2;9(1):1769. doi: 10.1038/s41467-018-04104-z.
8
Pyronaridine-artesunate or dihydroartemisinin-piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial.吡喹酮-青蒿琥酯或双氢青蒿素-哌喹与当前一线疗法用于复发性无并发症疟疾的多次治疗：一项随机、多中心、开放标签、纵向、对照、3b/4 期试验。
Lancet. 2018 Apr 7;391(10128):1378-1390. doi: 10.1016/S0140-6736(18)30291-5. Epub 2018 Mar 29.
9
Drug-Resistant Polymorphisms and Copy Numbers in Plasmodium falciparum, Mozambique, 2015.2015 年莫桑比克疟原虫的耐药多态性和拷贝数。
Emerg Infect Dis. 2018 Jan;24(1):40-48. doi: 10.3201/eid2401.170864.
10
Plasmodium falciparum Recrudescence Two Years after Treatment of an Uncomplicated Infection without Return to an Area Where Malaria Is Endemic.恶性疟原虫复燃 2 年，在无返回疟疾流行地区治疗单纯感染后。
Antimicrob Agents Chemother. 2018 Jan 25;62(2). doi: 10.1128/AAC.01892-17. Print 2018 Feb.
Zotero 插件