Kueh Y K, Teo C G
Ann Acad Med Singap. 1986 Apr;15(2):262-7.
Eosinophilic purpura, the syndrome of acquired platelet dysfunction with eosinophilia was first recognized in Singaporean children and later described in Thai children. It is a benign, transient thrombopathy associated with significant eosinophilia and characterized by the sudden onset of a superficial bleeding tendency. The first young adult with this haemostatic disturbance was documented in a National Servicemen 4 years ago. We report here our experience with 16 such patients (13 males, 3 females) and concur with the original observers on the benign nature of this syndrome. Stool helminths were present in 50% of the cases but the duration of symptoms and platelet dysfunction appeared unaffected by the rapidity with which the eosinophil count returned to normal following antihelminthic treatment. If platelet aggregation study is readily available it is desirable to document the presence of an abnormal platelet response to one or more aggregating agents but without it, it is still possible to diagnose this syndrome fairly confidently in the healthy, young patient in the first or second decade of life who develops recent onset bruising with or without mucosal bleeding, whose preliminary blood cell counts are normal apart from a moderate to marked absolute eosinophilia.
嗜酸性紫癜，即伴有嗜酸性粒细胞增多的获得性血小板功能障碍综合征，最初在新加坡儿童中被识别，后来在泰国儿童中也有描述。它是一种与显著嗜酸性粒细胞增多相关的良性、短暂性血栓病，其特征为突然出现的浅表出血倾向。4年前，一名年轻成人出现这种止血障碍，成为该病例的首次记录。我们在此报告我们对16例此类患者（13例男性，3例女性）的诊治经验，并认同该综合征本质为良性这一最初观察结果。50%的病例粪便中存在蠕虫，但症状持续时间和血小板功能障碍似乎不受抗蠕虫治疗后嗜酸性粒细胞计数恢复正常速度的影响。如果血小板聚集研究易于开展，最好记录血小板对一种或多种聚集剂的异常反应，但即便没有此项研究，对于处于生命第一个或第二个十年、近期出现瘀斑（伴或不伴有黏膜出血）、除中度至显著的绝对嗜酸性粒细胞增多外初步血细胞计数正常的健康年轻患者，仍有可能相当有把握地诊断此综合征。
