Linder Elkanah, Villén Johanna, Nekoro Marmar, Wettermark Björn, Sporrong Sofia Kälvemark
Department of Pharmacy, Uppsala University, Husargatan, SE-752 37 Uppsala, Sweden.
Swedish Knowledge Centre on Pharmaceuticals in the Environment, Swedish Medical Products Agency, P.O. Box 26, SE-751 03 Uppsala, Sweden.
Explor Res Clin Soc Pharm. 2023 Jul 8;11:100303. doi: 10.1016/j.rcsop.2023.100303. eCollection 2023 Sep.
Pharmaceuticals treat and prevent diseases but can pose a risk to organisms, predominantly in aquatic environments. The use of pharmaceuticals is predicted to increase due to, among other factors, a growing and aging population and climate change. Therefore, it is important to develop mitigation strategies to prevent pharmaceutical residues from entering the environment. In Sweden, two public pharmaceutical web-based knowledge supports provide information on the environmental impact of pharmaceuticals.
To explore stakeholder perspectives, use and future opportunities related to two webbased knowledge supports publicizing environmental information on pharmaceuticals.
Stakeholders identified for their experience with the knowledge supports, pharmaceutical policy, and stakeholder collaboration were recruited using purposive and snowball sampling for semi-structured interviews. Interviews were conducted in person or via video calls. Respondents included twenty-one representatives from the pharmaceutical industry, regional and national authorities, academia, and an independent research institute. Interview transcripts were analyzed using content analysis.
Respondents valued having environmental information on pharmaceuticals publicly accessible on two well-known pharmaceutical knowledge supports. The knowledge supports have been used in Sweden and internationally. Perceived differences were recognized between the impact and perspectives of the two knowledge supports with a general preference for the Janusinfo knowledge support. The preference was especially identified regarding transparency and the use of the information in clinical practice. Barriers to impact were a lack of resources and decision-making criteria. Respondents believed that the impact and value of the knowledge supports could be improved with more authority involvement.
Public knowledge support providing environmental information on pharmaceuticals has been valuable across sectors, especially, among Drug and Therapeutics Committees. We believe the results from this study could be useful for other countries interested in implementing a similar system.
药物可治疗和预防疾病,但可能对生物构成风险,在水生环境中这种风险尤为突出。预计由于人口增长与老龄化以及气候变化等多种因素,药物的使用将会增加。因此,制定缓解策略以防止药物残留进入环境至关重要。在瑞典,有两个基于网络的公共药物知识支持平台提供有关药物环境影响的信息。
探讨与两个宣传药物环境信息的基于网络的知识支持平台相关的利益相关者观点、使用情况及未来机遇。
通过目的抽样和滚雪球抽样,招募在知识支持平台、药物政策及利益相关者合作方面有经验的利益相关者进行半结构化访谈。访谈通过面对面或视频通话进行。受访者包括来自制药行业、地区和国家当局、学术界以及一家独立研究机构的21名代表。使用内容分析法对访谈记录进行分析。
受访者重视在两个知名的药物知识支持平台上公开获取有关药物的环境信息。这些知识支持平台已在瑞典和国际上得到应用。人们认识到这两个知识支持平台在影响和观点上存在差异,普遍更倾向于Janusinfo知识支持平台。在透明度以及临床实践中信息的使用方面,这种偏好尤为明显。影响的障碍在于缺乏资源和决策标准。受访者认为,更多权威机构的参与可以提高知识支持平台的影响力和价值。
提供药物环境信息的公共知识支持平台在各个部门都具有重要价值,尤其是在药物与治疗委员会中。我们认为本研究结果可能对其他有兴趣实施类似系统的国家有用。